{"id":"W2884824167","doi":"10.1002/path.5139","title":"Lynch syndrome – cancer pathways, heterogeneity and immune escape","year":2018,"lang":"en","type":"review","venue":"The Journal of Pathology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Cancer Research UK","keywords":"Microsatellite instability; Lynch syndrome; Colorectal cancer; Cancer; DNA mismatch repair; Pathological; Biology; Oncology; Medicine; Cancer research; Bioinformatics; Microsatellite; Gene; Internal medicine; Genetics; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004192239,0.0004583231,0.0006719665,0.002014118,0.0002371595,0.0007489353,0.0004487153,0.0008227187,0.001702431],"category_scores_gemma":[0.0007131966,0.0001418067,0.0002753718,0.001118548,0.0004902696,0.0008646086,0.0006009584,0.0009724369,0.0006592689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004637332,"about_ca_system_score_gemma":0.0006745369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008391764,"about_ca_topic_score_gemma":0.001177685,"domain_scores_codex":[0.9998707,0.00002760161,0.00002172765,0.00002566376,0.00003913346,0.00001532408],"domain_scores_gemma":[0.9997543,0.0001199451,0.00004675709,0.000006639488,0.00004285118,0.00002952112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009057769,0.00003206516,0.001046982,0.01205097,0.00009323813,0.001242939,0.0001577479,0.0003521703,0.002286623,0.007312973,0.02643414,0.9488996],"study_design_scores_gemma":[0.00001190672,0.00009313351,0.003336531,0.005134044,0.00009976637,0.01172634,0.0001591965,0.00009167405,0.0006318874,0.004237593,0.9744546,0.00002332436],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002066968,0.9988173,0.00006965676,0.0003643981,0.00008150934,0.000001676302,0.000008441149,0.000003792295,0.0004465353],"genre_scores_gemma":[0.002044507,0.997088,0.0001224688,0.0001573968,0.0001976363,0.000003542026,0.00002142942,8.820172e-7,0.0003640513],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002014118,"threshold_uncertainty_score":0.005695164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06927968329431491,"score_gpt":0.3599667998106388,"score_spread":0.2906871165163238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}