{"id":"W2884824167","doi":"10.1002/path.5139","title":"Lynch syndrome – cancer pathways, heterogeneity and immune escape","year":2018,"lang":"en","type":"review","venue":"The Journal of Pathology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Cancer Research UK","keywords":"Microsatellite instability; Lynch syndrome; Colorectal cancer; Cancer; DNA mismatch repair; Pathological; Biology; Oncology; Medicine; Cancer research; Bioinformatics; Microsatellite; Gene; Internal medicine; Genetics; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001345788,0.0003720384,0.002246738,0.0001943485,0.00007985055,0.00001080585,0.0003918096,0.0004260102,0.0002647526],"category_scores_gemma":[0.0001675525,0.0002000619,0.0004401329,0.0001823381,0.0004503716,0.00002790982,0.0001985137,0.0009268334,0.00002546094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001940681,"about_ca_system_score_gemma":0.0006107904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001154699,"about_ca_topic_score_gemma":0.00002100489,"domain_scores_codex":[0.9975544,0.0006106306,0.0009911231,0.0002154764,0.0002983105,0.0003300823],"domain_scores_gemma":[0.9976941,0.00026864,0.001156216,0.0004922299,0.0002352979,0.0001534895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003262703,0.0001643155,0.0002448546,0.01191241,0.001564253,0.004087031,0.0005320638,0.000001178977,0.0008223733,0.00001755668,0.001968919,0.9783587],"study_design_scores_gemma":[0.0009276791,0.003477674,0.002231258,0.01176259,0.006511904,0.2606294,0.00003140735,0.000001809253,0.0001725453,0.0001548729,0.7137221,0.0003767609],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09262865,0.9051868,0.00001480545,0.0001083236,0.001513841,0.0004006911,0.00002952594,0.000008460966,0.0001089572],"genre_scores_gemma":[0.007560768,0.9912893,0.0002466676,0.0001294179,0.0005682072,0.0000168641,0.00000362274,0.00006002893,0.0001251115],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.977982,"threshold_uncertainty_score":0.8158288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06927968329431491,"score_gpt":0.3599667998106388,"score_spread":0.2906871165163238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}