{"id":"W2884860115","doi":"10.1038/s41467-018-05221-5","title":"Enzymatic one-step ring contraction for quinolone biosynthesis","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Fonds de recherche du Québec – Nature et technologies; Princess Takamatsu Cancer Research Fund; Division of Chemistry; Takeda Science Foundation; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Uehara Memorial Foundation; National Institutes of Health; National Science Foundation","keywords":"Bicyclic molecule; Chemistry; Biosynthesis; Enzyme; Drug discovery; Quinolone; Stereochemistry; Biochemistry; Combinatorial chemistry; Antibiotics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002811736,0.0003917304,0.0004843446,0.0001865064,0.0002941702,0.0005705761,0.0005435818,0.0004080478,0.003085482],"category_scores_gemma":[0.0005180175,0.0001671651,0.0006809559,0.0002641726,0.0003247286,0.0005479875,0.000398578,0.000467039,0.000727514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004697279,"about_ca_system_score_gemma":0.0006284797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001282181,"about_ca_topic_score_gemma":0.001898765,"domain_scores_codex":[0.9998947,0.00002110547,0.000004992392,0.00002660681,0.00003133324,0.00002115756],"domain_scores_gemma":[0.9999101,0.00003581025,0.00001807931,0.00001707837,0.000009936128,0.00000893737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009364762,0.0003805629,0.01466229,0.002389577,0.0003273063,0.001605342,0.0003235036,0.4970466,0.2368512,0.07921678,0.004004209,0.1622563],"study_design_scores_gemma":[0.0002292142,0.0007665088,0.003239707,0.0000715865,0.0001622153,0.0007276456,0.0001934966,0.8442018,0.1035005,0.01844846,0.0283658,0.00009306955],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.853372,0.004886476,0.1137511,0.0004744724,0.0001069195,0.0001334867,0.001212428,0.001472355,0.02459087],"genre_scores_gemma":[0.9583138,0.001698002,0.03737715,0.00005147674,0.0000119958,0.00005688351,0.0009167121,0.00005852363,0.001515561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003085482,"threshold_uncertainty_score":0.01032203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0433190013364698,"score_gpt":0.3232866629797833,"score_spread":0.2799676616433134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}