{"id":"W2884860115","doi":"10.1038/s41467-018-05221-5","title":"Enzymatic one-step ring contraction for quinolone biosynthesis","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Fonds de recherche du Québec – Nature et technologies; Princess Takamatsu Cancer Research Fund; Division of Chemistry; Takeda Science Foundation; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Uehara Memorial Foundation; National Institutes of Health; National Science Foundation","keywords":"Bicyclic molecule; Chemistry; Biosynthesis; Enzyme; Drug discovery; Quinolone; Stereochemistry; Biochemistry; Combinatorial chemistry; Antibiotics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002979172,0.0001282029,0.0002476414,0.0001267946,0.000412582,0.00003058272,0.0003930982,0.000324199,0.00008332825],"category_scores_gemma":[0.00135182,0.0001068613,0.0001119334,0.0002554266,0.0002044225,0.0001012744,0.0001020709,0.0005300495,0.00007304837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007845112,"about_ca_system_score_gemma":0.00005196125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002552496,"about_ca_topic_score_gemma":0.0002464447,"domain_scores_codex":[0.9991395,0.00005788696,0.0002562382,0.0002189693,0.0001207924,0.0002065509],"domain_scores_gemma":[0.9974594,0.000431233,0.0001298686,0.001443872,0.0004637956,0.00007185825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003025705,0.0006001604,0.0002890404,0.0001486831,0.0002959095,5.094974e-7,0.0002026605,7.434735e-8,0.9078346,0.01466143,0.02503261,0.05063175],"study_design_scores_gemma":[0.0008036002,0.0002366581,0.005825225,0.0002982534,0.0004298517,0.00003457377,0.0001022518,0.0007021044,0.3885001,0.0002242089,0.602596,0.0002472124],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4734789,0.03790741,0.003067314,0.4288713,0.00277572,0.008397484,0.0003924383,0.001416964,0.04369251],"genre_scores_gemma":[0.9536075,0.0004405536,0.04349462,0.001327364,0.0004646604,0.00001321592,0.00006635916,0.00002256081,0.0005631687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5775634,"threshold_uncertainty_score":0.4357677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0433190013364698,"score_gpt":0.3232866629797833,"score_spread":0.2799676616433134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}