{"id":"W2884962542","doi":"10.1017/cjn.2018.59","title":"Response to the Canadian Agency for Drugs and Technologies in Health and Institut national d’excellence en santé et en services sociaux decision regarding nusinersen for Spinal Muscular Atrophy","year":2018,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agricultural Research Institute of Ontario; Hospital for Sick Children; University of Ottawa; McGill University; University of Calgary; Children's Hospital of Western Ontario; Children's Hospital of Eastern Ontario; Montreal Neurological Institute and Hospital; SickKids Foundation; Western University; University of Toronto; BC Children's Hospital; London Health Sciences Centre","funders":"","keywords":"Excellence; Agency (philosophy); Spinal muscular atrophy; Medicine; Political science; Family medicine; Sociology; Internal medicine; Disease; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":["sts"],"category_scores_codex":[0.01020295,0.0002082943,0.000366075,0.001288376,0.00266252,0.0004074064,0.0008863495,0.0001527196,0.000006580467],"category_scores_gemma":[0.00661338,0.0001301371,0.0001138924,0.0009319493,0.002809103,0.0003280733,0.00008651961,0.0006032242,4.877912e-7],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003964482,"about_ca_system_score_gemma":0.008192279,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01727171,"about_ca_topic_score_gemma":0.6625205,"domain_scores_codex":[0.9965545,0.0007732658,0.0005367733,0.0004870601,0.0006544055,0.0009939973],"domain_scores_gemma":[0.9967825,0.001038399,0.0002400771,0.0001092921,0.0005266431,0.001303129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005257865,0.00008356819,0.7845097,0.0002348467,0.00007373214,0.002129974,0.01403224,0.001696704,0.0004943305,0.005082894,0.002067452,0.1843367],"study_design_scores_gemma":[0.00241297,0.1589229,0.6818483,0.000548779,0.00005171912,0.0146443,0.007385881,0.005446553,0.00008416676,0.03772089,0.09030279,0.0006307404],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9297253,0.002015186,0.0001247455,0.06712779,0.0002112401,0.0006301877,0.00001583133,0.000008512434,0.0001411668],"genre_scores_gemma":[0.9854786,0.0008797924,0.005939357,0.007537017,0.0001320876,0.00001520151,3.448643e-7,0.000009201375,0.000008348241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6452488,"threshold_uncertainty_score":0.9999047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03998037959415977,"score_gpt":0.362696304742736,"score_spread":0.3227159251485762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}