{"id":"W2885044233","doi":"10.1111/imb.12529","title":"CRISPR/Cas9‐mediated disruption of the <i>immediate early‐0</i> and <i>2</i> as a therapeutic approach to <i>Bombyx mori</i> nucleopolyhedrovirus in transgenic silkworm","year":2018,"lang":"en","type":"article","venue":"Insect Molecular Biology","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"China Agricultural Research System; National Natural Science Foundation of China","keywords":"CRISPR; Biology; Transgene; Cas9; Gene; Genome editing; Bombyx; Genetics; Bombyx mori; Virology; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001306078,0.0004470175,0.0003042081,0.0002016934,0.0001771803,0.0002985641,0.000294276,0.0004116832,0.0010098],"category_scores_gemma":[0.00006341578,0.0001966754,0.0003472427,0.0001238999,0.0002355411,0.0001571411,0.000264647,0.0007080912,0.0002935774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003087528,"about_ca_system_score_gemma":0.0002362959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001114635,"about_ca_topic_score_gemma":0.001461335,"domain_scores_codex":[0.9998374,0.00001463991,0.00001964153,0.00004507191,0.00005346983,0.0000296462],"domain_scores_gemma":[0.9999443,0.000005153428,0.00002323103,0.000006080694,0.000005202131,0.00001595604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001386084,0.00000602225,0.00003849647,0.00002197365,0.000003170448,0.00002703287,0.000004924254,0.00003722352,0.9993123,0.0000686025,0.00002994293,0.0004364223],"study_design_scores_gemma":[0.00001092081,0.00008799369,0.001289396,0.000005256982,0.00002137152,0.0003152007,0.00001111753,0.001173101,0.9931087,0.0000285156,0.00394119,0.000007156569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9474371,0.002017933,0.04300069,0.0002109024,0.0001414935,0.0002242948,0.001448514,0.0009775226,0.004541554],"genre_scores_gemma":[0.9709609,0.001061422,0.01915623,0.0001037748,0.00001480509,0.0001235097,0.001298574,0.00009761601,0.00718314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001114635,"threshold_uncertainty_score":0.003378093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009680824923323346,"score_gpt":0.2731753800694586,"score_spread":0.2634945551461353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}