{"id":"W2885044233","doi":"10.1111/imb.12529","title":"CRISPR/Cas9‐mediated disruption of the <i>immediate early‐0</i> and <i>2</i> as a therapeutic approach to <i>Bombyx mori</i> nucleopolyhedrovirus in transgenic silkworm","year":2018,"lang":"en","type":"article","venue":"Insect Molecular Biology","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"China Agricultural Research System; National Natural Science Foundation of China","keywords":"CRISPR; Biology; Transgene; Cas9; Gene; Genome editing; Bombyx; Genetics; Bombyx mori; Virology; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001969898,0.0002904761,0.0002931263,0.0001110989,0.0001130363,0.0000210555,0.0003626757,0.0003252384,0.00001251664],"category_scores_gemma":[0.000104518,0.0002228509,0.0001746514,0.0004030603,0.0004164138,0.000007094333,0.0002193737,0.0001768089,0.00001597837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001822168,"about_ca_system_score_gemma":0.0000965791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000495372,"about_ca_topic_score_gemma":0.0001164837,"domain_scores_codex":[0.9981076,0.0003055373,0.0003857926,0.0006147754,0.0001481563,0.0004381403],"domain_scores_gemma":[0.9990057,0.00002514141,0.0001349566,0.0005817311,0.00009798691,0.0001544545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003315932,0.0001866091,0.008539592,0.00002133153,0.00006489298,0.000001918793,0.0002902437,0.00001606767,0.9889649,0.0005078905,0.0001412829,0.0009336345],"study_design_scores_gemma":[0.001952535,0.002405751,0.02195826,0.00004059479,0.00006352556,0.00004334563,0.00006913625,0.00006850142,0.9645048,0.002373425,0.005991303,0.0005288711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936426,0.001261638,0.002219949,0.0001577598,0.0003647899,0.0005768094,0.00005994721,0.00001980593,0.001696659],"genre_scores_gemma":[0.9957954,0.0001793412,0.000122666,0.003519085,0.0001542758,0.0001022698,0.0000431959,0.00004282217,0.00004094989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02446019,"threshold_uncertainty_score":0.9087596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009680824923323346,"score_gpt":0.2731753800694586,"score_spread":0.2634945551461353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}