{"id":"W2885056221","doi":"10.1186/1477-5956-9-s1-s6","title":"Prediction of 492 human protein kinase substrate specificities","year":2011,"lang":"en","type":"article","venue":"Proteome Science","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Kinexus Bioinformatics Corporation (Canada); University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Kinase; Biology; MAP2K7; Protein kinase domain; Computational biology; Protein kinase A; Cell biology; Phosphorylation; Biochemistry; Cyclin-dependent kinase 2; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004228534,0.00008304242,0.00007530264,0.00005392149,0.0001318105,0.00001969111,0.0003000744,0.00005575606,0.00003658703],"category_scores_gemma":[0.00001557444,0.00007325942,0.00003221359,0.0001569831,0.0005469886,0.00001257471,0.00009615499,0.00005870195,0.000006563411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008784334,"about_ca_system_score_gemma":0.00007598744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002216236,"about_ca_topic_score_gemma":0.00000581503,"domain_scores_codex":[0.9992204,0.00001016194,0.0002121359,0.0001922699,0.0001546324,0.0002104085],"domain_scores_gemma":[0.9994453,7.061172e-7,0.0001133635,0.0002800026,0.00009770728,0.00006291489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001569316,0.00002639503,0.0005359037,0.0000204413,0.000003611573,3.943516e-7,0.0002030898,0.000004769169,0.9964094,0.002058912,0.00003508113,0.0006862669],"study_design_scores_gemma":[0.0001388839,0.0003077615,0.006055384,0.00002236206,0.000002682529,0.000003270331,0.0001128908,0.0001238454,0.9905373,0.002146655,0.0004611511,0.00008777674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832039,0.0000739057,0.002294978,0.000008775874,0.00007420075,0.0003919684,0.0000154809,0.000009454717,0.01392731],"genre_scores_gemma":[0.9956129,0.000008025732,0.003817038,0.00001319439,0.00007154656,0.00003498622,0.000008243072,0.000005559235,0.0004285614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01349875,"threshold_uncertainty_score":0.2987432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03783503286541123,"score_gpt":0.2265170232442524,"score_spread":0.1886819903788412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}