{"id":"W2885067288","doi":"10.1021/acs.jmedchem.8b00683","title":"Discovery of 3-Benzyl-1-(<i>trans</i>-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors","year":2018,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Chemistry; Synthetic lethality; Kinase; Cyclin-dependent kinase; Drug discovery; RNA polymerase II; DNA; Biochemistry; DNA repair; Gene; Cell cycle; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001162808,0.0003394383,0.0002666118,0.0001839301,0.0001159743,0.0002322192,0.0003182316,0.000171889,0.001251966],"category_scores_gemma":[0.0001066604,0.0001239718,0.0001629303,0.0001660966,0.0001265296,0.0001725275,0.0001835951,0.0003651619,0.000382013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002676969,"about_ca_system_score_gemma":0.0002422227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008477491,"about_ca_topic_score_gemma":0.002758014,"domain_scores_codex":[0.9999404,0.00001211027,0.000003992398,0.00001079596,0.00001440636,0.00001838147],"domain_scores_gemma":[0.9999659,0.000003520074,0.00001052054,0.000003305066,0.000007392989,0.00000942976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004023692,0.0002301519,0.000573826,0.000332393,0.00003218441,0.0003876101,0.00006289616,0.001988304,0.9580849,0.00174856,0.0009337452,0.03522312],"study_design_scores_gemma":[0.0002940249,0.002689034,0.003303064,0.00004587525,0.00007573207,0.0008257014,0.00003881341,0.004179723,0.9616936,0.0002621174,0.02656409,0.00002816074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9386789,0.02408878,0.01528797,0.0005609039,0.0001876027,0.0002990387,0.001018988,0.0003657607,0.01951203],"genre_scores_gemma":[0.9790797,0.009566414,0.006729911,0.0001743847,0.00003640441,0.00006025069,0.0005971866,0.0000294822,0.003726272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251966,"threshold_uncertainty_score":0.00418824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019075306969103,"score_gpt":0.2575551865197033,"score_spread":0.2473644334500123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}