{"id":"W2885067288","doi":"10.1021/acs.jmedchem.8b00683","title":"Discovery of 3-Benzyl-1-(<i>trans</i>-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors","year":2018,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Chemistry; Synthetic lethality; Kinase; Cyclin-dependent kinase; Drug discovery; RNA polymerase II; DNA; Biochemistry; DNA repair; Gene; Cell cycle; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00054383,0.0004323841,0.001003803,0.0002022245,0.000103762,0.00002837565,0.0002538214,0.0003558216,0.0001160393],"category_scores_gemma":[0.0008289657,0.0003650281,0.0003108218,0.0003433127,0.0008166814,0.0002965528,0.00009061708,0.001194297,0.000002430186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002855954,"about_ca_system_score_gemma":0.0009655399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007987555,"about_ca_topic_score_gemma":0.0000133959,"domain_scores_codex":[0.9965245,0.00004640281,0.001205057,0.0004336934,0.001329379,0.0004609258],"domain_scores_gemma":[0.9971445,0.0002032764,0.001049073,0.0003738245,0.0007333946,0.000495972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002288242,0.0004664221,0.002010931,0.0004764398,0.0005131171,0.0004985792,0.001156479,0.000006182774,0.989975,0.00001238472,0.001439949,0.00115631],"study_design_scores_gemma":[0.006779246,0.002116787,0.003638111,0.00198445,0.0007314653,0.00538766,0.001196807,0.00003069878,0.9758765,0.0001480201,0.001806144,0.0003040972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874985,0.002794413,0.002200571,0.001179073,0.0005166426,0.0002743596,0.00003581114,0.00002301166,0.005477633],"genre_scores_gemma":[0.9957898,0.0006839912,0.0007000517,0.000360205,0.001964587,0.000005565493,0.00001169403,0.00006376416,0.0004203557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01409845,"threshold_uncertainty_score":0.9998802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019075306969103,"score_gpt":0.2575551865197033,"score_spread":0.2473644334500123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}