{"id":"W2885068254","doi":"10.1158/1538-7445.am2018-1936","title":"Abstract 1936: The central role of NFAT signalling in the mechanism of action of the TRPV6 oncochannel inhibitor and clinical candidate SOR-C13","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Allison University","funders":"","keywords":"NFAT; Prostate cancer; Cancer research; Reporter gene; Transfection; Medicine; Biology; Chemistry; Internal medicine; Calcineurin; Cell culture; Gene expression; Cancer; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002102671,0.0003668172,0.0004501913,0.0001790077,0.0001694673,0.0004144453,0.0002212885,0.0003179992,0.006182322],"category_scores_gemma":[0.0001420561,0.0001006979,0.0003370024,0.000177015,0.0002166207,0.0002043853,0.0001229091,0.001120279,0.001131863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003191713,"about_ca_system_score_gemma":0.0003643894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002822514,"about_ca_topic_score_gemma":0.0006936967,"domain_scores_codex":[0.9998959,0.00001487927,0.000008725633,0.00001715727,0.00003481749,0.000028498],"domain_scores_gemma":[0.9999444,0.00000695062,0.0000134982,0.000003976003,0.00001228949,0.00001891274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004318638,0.0004136548,0.0005853033,0.0004858359,0.00004748909,0.0001583506,0.00002814446,0.0003051921,0.959978,0.0004639934,0.001621229,0.03159407],"study_design_scores_gemma":[0.002040542,0.009302774,0.01505607,0.000098807,0.0001605349,0.002163814,0.0001129335,0.002103125,0.9226354,0.0006999109,0.04559193,0.00003413617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9211553,0.04046757,0.01039621,0.002660439,0.0007096084,0.0005371785,0.005507839,0.0007098067,0.01785605],"genre_scores_gemma":[0.9754671,0.007173605,0.003760314,0.0005034332,0.0001223999,0.0002109115,0.003027424,0.00005609162,0.009678583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006182322,"threshold_uncertainty_score":0.02068192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07705651906599703,"score_gpt":0.4153374700789012,"score_spread":0.3382809510129042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}