{"id":"W2885098219","doi":"10.1158/1538-7445.am2018-110","title":"Abstract 110: PPARγ loss increases the metastatic potential of HER2+ breast cancer","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Peroxisome proliferator-activated receptor; Cancer research; Carcinogenesis; Internal medicine; Breast cancer; Metastatic breast cancer; Metastasis; Endocrinology; Tumor progression; Cancer; Medicine; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009664748,0.0003329463,0.0003395108,0.0003991088,0.0002178697,0.0003649286,0.0001948527,0.0004353199,0.006616211],"category_scores_gemma":[0.0000638929,0.0002141806,0.0002763481,0.0002951318,0.0002638132,0.0001991907,0.0002298981,0.0010902,0.0009541592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004779896,"about_ca_system_score_gemma":0.0002706089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001238074,"about_ca_topic_score_gemma":0.001549568,"domain_scores_codex":[0.9998137,0.00001760192,0.00001464731,0.00004078943,0.00006226708,0.00005098606],"domain_scores_gemma":[0.9999006,0.000006874302,0.00002780852,0.000008996049,0.000008457551,0.00004731739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004242945,0.0001470518,0.0005038728,0.00004706435,0.000009585029,0.00006571627,0.00001156669,0.0000609105,0.9967906,0.0001218575,0.0003725169,0.00144487],"study_design_scores_gemma":[0.00009924611,0.001446165,0.0163141,0.00001852495,0.00005071698,0.0008341742,0.000104251,0.0008808862,0.9734566,0.0001225706,0.006663269,0.000009638955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905452,0.001478916,0.001176723,0.0004463112,0.0001055968,0.00004449892,0.002037469,0.0001992338,0.003966146],"genre_scores_gemma":[0.9794836,0.001295268,0.0009431992,0.0002559448,0.00002738605,0.00009556592,0.002599446,0.00005377845,0.01524577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006616211,"threshold_uncertainty_score":0.02213341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0349456361641638,"score_gpt":0.3764722958599897,"score_spread":0.3415266596958259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}