{"id":"W2885107163","doi":"10.1200/jco.2018.79.1483","title":"Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":978,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Medicine; Hazard ratio; Surgery; Esophagectomy; Clinical endpoint; Radiation therapy; Chemoradiotherapy; Esophagus; Neoadjuvant therapy; Neutropenia; Leukopenia; Phases of clinical research; Esophageal cancer; Gastroenterology; Internal medicine; Randomized controlled trial; Chemotherapy; Cancer; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01717605,0.0003837644,0.007265849,0.0001641942,0.0001453522,0.00003082111,0.0006924041,0.000591922,0.0002915264],"category_scores_gemma":[0.02140357,0.0002272587,0.002939117,0.0002910256,0.001488181,0.0001985903,0.0001689074,0.001145615,0.00001062996],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003297777,"about_ca_system_score_gemma":0.007008074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009813041,"about_ca_topic_score_gemma":0.00006466891,"domain_scores_codex":[0.9886649,0.002386815,0.006822989,0.0005410131,0.0008830409,0.0007012707],"domain_scores_gemma":[0.9421736,0.04957071,0.005252742,0.0006919703,0.001350333,0.0009606496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.821167,0.021848,0.004913137,0.00005818936,0.0008048254,0.0005085515,0.00004017821,4.92597e-7,0.00007800465,0.000003460702,0.03965347,0.1109247],"study_design_scores_gemma":[0.9212268,0.06837375,0.0006842091,0.0001154633,0.001109905,0.00006024121,0.00003949492,0.0003315619,0.003874885,0.00004420269,0.003967355,0.0001721093],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9632571,0.0175452,0.0004604654,0.004688186,0.009289654,0.004540813,0.00005397329,0.00001234564,0.0001522793],"genre_scores_gemma":[0.9903451,0.001753934,0.002472232,0.001785002,0.002969883,0.0001541808,0.00001778602,0.00006137607,0.0004405234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1107526,"threshold_uncertainty_score":0.9986213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1956553790038129,"score_gpt":0.5140244621430774,"score_spread":0.3183690831392645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}