{"id":"W2885107163","doi":"10.1200/jco.2018.79.1483","title":"Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":978,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Medicine; Hazard ratio; Surgery; Esophagectomy; Clinical endpoint; Radiation therapy; Chemoradiotherapy; Esophagus; Neoadjuvant therapy; Neutropenia; Leukopenia; Phases of clinical research; Esophageal cancer; Gastroenterology; Internal medicine; Randomized controlled trial; Chemotherapy; Cancer; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00242283,0.001960276,0.002740355,0.0004645652,0.0003857505,0.0009214709,0.001035931,0.001777635,0.004742248],"category_scores_gemma":[0.001338519,0.000667243,0.001641745,0.0004912629,0.001490723,0.001051141,0.0004247406,0.002481767,0.0007953634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007170372,"about_ca_system_score_gemma":0.001406791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006803822,"about_ca_topic_score_gemma":0.002155094,"domain_scores_codex":[0.9992435,0.0004917036,0.00003586478,0.00009559429,0.00004133554,0.00009201792],"domain_scores_gemma":[0.9989954,0.0002540419,0.0002282748,0.00008048415,0.0000464211,0.0003953681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9701658,0.01648676,0.0005544547,0.0002574296,0.0003688289,0.00003053667,0.00003588617,0.0003692593,0.003276362,0.00006250029,0.0004671376,0.007924993],"study_design_scores_gemma":[0.8385908,0.1587643,0.0009801926,0.00001929386,0.0002268814,0.00002994122,0.00001780654,0.0005247308,0.0004880003,0.00008065247,0.000265319,0.00001210261],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934345,0.001312368,0.0003959946,0.0004377609,0.0003778061,0.002728674,0.0004326004,0.00006857551,0.000811737],"genre_scores_gemma":[0.9854373,0.001841589,0.001761671,0.001236838,0.000586467,0.005772196,0.0007681765,0.00001846961,0.002577209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004742248,"threshold_uncertainty_score":0.01586437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1956553790038129,"score_gpt":0.5140244621430774,"score_spread":0.3183690831392645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}