{"id":"W2885138738","doi":"10.21037/atm.2018.07.04","title":"ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia","year":2018,"lang":"en","type":"article","venue":"Annals of Translational Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Qingdao Key Health Discipline Development Fund; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; National Natural Science Foundation of China; Eisai; Genentech; IXICO; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Cerebrospinal fluid; Dementia; Genotype; Medicine; Disease; Alzheimer's disease; Pathology; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003934928,0.0004010442,0.0004872232,0.0005841625,0.0003334529,0.0006538364,0.0002203033,0.0005018359,0.003141854],"category_scores_gemma":[0.001773678,0.0001827121,0.0003632571,0.0004784031,0.000296425,0.0003207294,0.0002140301,0.0003826782,0.0003750578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002314564,"about_ca_system_score_gemma":0.0001831405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002034177,"about_ca_topic_score_gemma":0.001584625,"domain_scores_codex":[0.9997731,0.00005646945,0.00003920674,0.00007230285,0.00003090726,0.00002805389],"domain_scores_gemma":[0.9993407,0.0001633942,0.0002178622,0.00006897432,0.0001242891,0.00008471786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005262917,0.0002299348,0.9590306,0.0001129917,0.0006211877,0.001537636,0.000319239,0.00007920898,0.02336076,0.0001765191,0.0004105128,0.008858465],"study_design_scores_gemma":[0.00004560015,0.000442355,0.9949549,0.00001836387,0.0003305867,0.001625067,0.0001009358,0.000252091,0.001331431,0.0004067182,0.0004828825,0.00000914153],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988128,0.0004264334,0.0001049838,0.00004713384,0.00001971252,0.000004944747,0.0002024192,0.000005928074,0.0003754839],"genre_scores_gemma":[0.9993902,0.00008457393,0.00009038326,0.00003014368,0.00001181071,0.000004966586,0.0001698691,0.000005216686,0.0002129155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003141854,"threshold_uncertainty_score":0.01051056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1651264325709793,"score_gpt":0.4176464593623366,"score_spread":0.2525200267913573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}