{"id":"W2885145075","doi":"10.1158/1538-7445.am2018-ct115","title":"Abstract CT115: Updated survival results of the KEYNOTE-040 study of pembrolizumab vs standard-of-care chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Docetaxel; Pembrolizumab; Population; Internal medicine; Oncology; Hazard ratio; Clinical endpoint; Cetuximab; Regimen; Head and neck squamous-cell carcinoma; Confidence interval; Progression-free survival; Head and neck cancer; Surgery; Chemotherapy; Radiation therapy; Cancer; Randomized controlled trial; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000898173,0.0001858806,0.000822229,0.0001534748,0.000178586,0.00001001903,0.0002409611,0.0000580271,0.00009418153],"category_scores_gemma":[0.000311893,0.0001129151,0.00009704867,0.0005486708,0.000528733,0.00003965979,0.0001232456,0.0002886412,7.153635e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002047863,"about_ca_system_score_gemma":0.001031787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001582168,"about_ca_topic_score_gemma":0.004665698,"domain_scores_codex":[0.9974177,0.0001808113,0.0005983477,0.0004031085,0.0009576426,0.0004423942],"domain_scores_gemma":[0.9968917,0.0004100358,0.0002023477,0.0005705372,0.001804351,0.0001210723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6932938,0.004078682,0.05570816,0.01321266,0.0008600143,0.000037707,0.0941449,0.00001212321,0.03855911,0.00004696755,0.03302184,0.0670241],"study_design_scores_gemma":[0.08695211,0.08500957,0.417694,0.001224973,0.0003142242,0.000004757519,0.0263482,0.00006158763,0.3662935,0.00004793989,0.01568317,0.00036601],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923182,0.002923903,0.000002177075,0.000725404,0.0002248869,0.002389776,0.0006673291,0.000009477855,0.0007388821],"genre_scores_gemma":[0.9989262,0.0003507224,0.00007148639,0.00002488183,0.0001384993,0.0001387123,0.00001127521,0.00003622479,0.0003019727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6063417,"threshold_uncertainty_score":0.4604545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1165635088330445,"score_gpt":0.4392610815519765,"score_spread":0.322697572718932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}