{"id":"W2885145075","doi":"10.1158/1538-7445.am2018-ct115","title":"Abstract CT115: Updated survival results of the KEYNOTE-040 study of pembrolizumab vs standard-of-care chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Docetaxel; Pembrolizumab; Population; Internal medicine; Oncology; Hazard ratio; Clinical endpoint; Cetuximab; Regimen; Head and neck squamous-cell carcinoma; Confidence interval; Progression-free survival; Head and neck cancer; Surgery; Chemotherapy; Radiation therapy; Cancer; Randomized controlled trial; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01112418,0.0009570897,0.00161717,0.0006633786,0.0003329266,0.001483606,0.001217563,0.001040975,0.004231692],"category_scores_gemma":[0.009346834,0.0003901999,0.002702186,0.001193136,0.0004364523,0.001160976,0.0008042016,0.00183106,0.0006835841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001162524,"about_ca_system_score_gemma":0.001052371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001902354,"about_ca_topic_score_gemma":0.003898408,"domain_scores_codex":[0.9952305,0.003010733,0.0003142309,0.000586406,0.0006708231,0.0001872578],"domain_scores_gemma":[0.9912797,0.003690984,0.002270656,0.001069843,0.0007957186,0.0008931326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7086743,0.001473653,0.1297285,0.003762746,0.03465156,0.0003152587,0.0002672691,0.005265631,0.01090581,0.000541707,0.02327296,0.08114062],"study_design_scores_gemma":[0.1662703,0.07052901,0.6810896,0.0005934153,0.05380863,0.0008487932,0.0001616891,0.00386877,0.003829609,0.0006427523,0.01819866,0.0001587794],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9161171,0.02283584,0.001971833,0.00136632,0.0004435078,0.001361079,0.046014,0.0002634224,0.009626821],"genre_scores_gemma":[0.9680972,0.001763601,0.0007476655,0.0009440887,0.0003686041,0.0004253138,0.02555967,0.0000612581,0.002032686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01112418,"threshold_uncertainty_score":0.05883098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1165635088330445,"score_gpt":0.4392610815519765,"score_spread":0.322697572718932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}