{"id":"W2885210084","doi":"10.1016/j.cllc.2018.07.008","title":"Cell-Free DNA Next-Generation Sequencing Prediction of Response and Resistance to Third-Generation EGFR Inhibitor","year":2018,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Infection and Immunity; Clovis Oncology","keywords":"T790M; Liquid biopsy; Lung cancer; Medicine; Cancer research; KRAS; Cell-free fetal DNA; DNA sequencing; Resistance mutation; Oncology; Gene; Osimertinib; Exon; EGFR inhibitors; Internal medicine; Epidermal growth factor receptor; Gefitinib; Cancer; Polymerase chain reaction; Erlotinib; Biology; Genetics; Reverse transcriptase; Colorectal cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005753714,0.0001319917,0.0002707923,0.00008197925,0.0001467247,0.00002857745,0.00006114053,0.0001393596,0.00006641916],"category_scores_gemma":[0.0005130312,0.0001135725,0.00007018286,0.0002103899,0.0001310526,0.0001631522,0.00004024666,0.0001206384,0.000006676825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004290177,"about_ca_system_score_gemma":0.0005553008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000722589,"about_ca_topic_score_gemma":0.0005024044,"domain_scores_codex":[0.9984698,0.0001353733,0.000582709,0.0004015937,0.0002428471,0.0001676899],"domain_scores_gemma":[0.9987464,0.0001361074,0.0001636809,0.0003995028,0.0003656624,0.0001886487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003171002,0.0002284349,0.04366793,0.0001799027,0.0002352866,0.000009746641,0.001856824,0.0000393238,0.6805011,0.0002502719,0.2660965,0.00376365],"study_design_scores_gemma":[0.02203538,0.008432309,0.3643463,0.002224918,0.00375686,0.00002088364,0.0007037878,0.02401647,0.5049332,0.0003925288,0.06815369,0.0009836985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904194,0.001514757,0.0009049629,0.003540751,0.001280359,0.0007433933,0.0001251756,0.00005055203,0.001420612],"genre_scores_gemma":[0.9878961,0.000252793,0.004038038,0.00123544,0.002970711,0.0001250022,0.00004958202,0.00002390786,0.003408356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3206783,"threshold_uncertainty_score":0.4631352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0895180354257775,"score_gpt":0.3965163339387146,"score_spread":0.3069982985129371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}