{"id":"W2885210084","doi":"10.1016/j.cllc.2018.07.008","title":"Cell-Free DNA Next-Generation Sequencing Prediction of Response and Resistance to Third-Generation EGFR Inhibitor","year":2018,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Infection and Immunity; Clovis Oncology","keywords":"T790M; Liquid biopsy; Lung cancer; Medicine; Cancer research; KRAS; Cell-free fetal DNA; DNA sequencing; Resistance mutation; Oncology; Gene; Osimertinib; Exon; EGFR inhibitors; Internal medicine; Epidermal growth factor receptor; Gefitinib; Cancer; Polymerase chain reaction; Erlotinib; Biology; Genetics; Reverse transcriptase; Colorectal cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007092779,0.0003062997,0.00062519,0.0004312967,0.0001800692,0.0008096208,0.0003892651,0.0008907486,0.001287126],"category_scores_gemma":[0.00181657,0.0002135395,0.0004122202,0.0002862446,0.0002287783,0.0002481837,0.0002209316,0.0006588767,0.0003793755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004675691,"about_ca_system_score_gemma":0.0004919356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001755144,"about_ca_topic_score_gemma":0.003676012,"domain_scores_codex":[0.9995039,0.00008730023,0.00002581545,0.0001596605,0.0001774064,0.00004590012],"domain_scores_gemma":[0.9992022,0.0004866604,0.00008272402,0.0000498411,0.0001288822,0.00004983511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005137441,0.0008900007,0.3246863,0.00058751,0.0009339019,0.0007577161,0.0004017379,0.03112973,0.4862872,0.001111555,0.003949754,0.1441272],"study_design_scores_gemma":[0.0004954626,0.003757582,0.2283833,0.0001426172,0.001449297,0.002761343,0.0003258129,0.3569917,0.3885952,0.002338905,0.01461592,0.0001428167],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832455,0.001860243,0.009422881,0.000317969,0.00009423854,0.00008551092,0.003405548,0.0001539649,0.001414181],"genre_scores_gemma":[0.9863181,0.0004201558,0.008053545,0.000420854,0.00003567219,0.00007629834,0.00314999,0.00002106571,0.001504329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001755144,"threshold_uncertainty_score":0.004305899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0895180354257775,"score_gpt":0.3965163339387146,"score_spread":0.3069982985129371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}