{"id":"W2885231949","doi":"10.1016/j.humimm.2018.08.007","title":"IL-8 analogue CXCL8 (3-72) K11R/G31P, modulates LPS-induced inflammation via AKT1-NF-kβ and ERK1/2-AP-1 pathways in THP-1 monocytes","year":2018,"lang":"en","type":"article","venue":"Human Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Royal University Hospital","funders":"National Natural Science Foundation of China","keywords":"Inflammation; Chemokine; Chemistry; CXC chemokine receptors; NF-κB; Receptor; Interleukin 8; Lipopolysaccharide; THP1 cell line; Signal transduction; IκBα; Molecular biology; Endocrinology; Internal medicine; Chemokine receptor; Biology; Biochemistry; Cell culture; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001454667,0.000308508,0.0002562106,0.0001529772,0.0002042878,0.0002785486,0.0002269804,0.0002714826,0.002846187],"category_scores_gemma":[0.0001280753,0.0001401791,0.0001699536,0.0001299503,0.0002313745,0.0002399089,0.0001404194,0.0006942592,0.000767371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002032292,"about_ca_system_score_gemma":0.0003794457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007285838,"about_ca_topic_score_gemma":0.001203375,"domain_scores_codex":[0.9998148,0.00003601506,0.00001584588,0.00002486406,0.00003611239,0.00007235029],"domain_scores_gemma":[0.9999541,0.000006607057,0.0000115292,0.000006889516,0.000005410454,0.00001542963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00241264,0.0002314578,0.0003429259,0.00009091009,0.000009270572,0.0001670855,0.00002105389,0.0001753846,0.9926701,0.0001192552,0.0003800039,0.003379998],"study_design_scores_gemma":[0.0007483168,0.002416997,0.01307123,0.0000298661,0.00005811302,0.0005792741,0.0001196707,0.001960803,0.9754877,0.0001919376,0.005320209,0.00001588963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946955,0.001407304,0.0006403463,0.0003686879,0.00008438778,0.000031334,0.0008396909,0.00006971716,0.001862908],"genre_scores_gemma":[0.9940871,0.0009544991,0.001235965,0.0001103679,0.00003575666,0.0000613399,0.0007155836,0.00001103196,0.002788248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002846187,"threshold_uncertainty_score":0.009521425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02089079123228367,"score_gpt":0.2435577486334844,"score_spread":0.2226669574012007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}