{"id":"W2885231949","doi":"10.1016/j.humimm.2018.08.007","title":"IL-8 analogue CXCL8 (3-72) K11R/G31P, modulates LPS-induced inflammation via AKT1-NF-kβ and ERK1/2-AP-1 pathways in THP-1 monocytes","year":2018,"lang":"en","type":"article","venue":"Human Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Royal University Hospital","funders":"National Natural Science Foundation of China","keywords":"Inflammation; Chemokine; Chemistry; CXC chemokine receptors; NF-κB; Receptor; Interleukin 8; Lipopolysaccharide; THP1 cell line; Signal transduction; IκBα; Molecular biology; Endocrinology; Internal medicine; Chemokine receptor; Biology; Biochemistry; Cell culture; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006594044,0.0004468299,0.0006328457,0.0007525245,0.0006726774,0.00005692551,0.0004201181,0.0008638093,0.000647586],"category_scores_gemma":[0.0001707472,0.0004417548,0.0001155279,0.0003145753,0.0007027864,0.0004706977,0.0003051412,0.000640988,0.001292927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000146943,"about_ca_system_score_gemma":0.00007901488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008835363,"about_ca_topic_score_gemma":0.0006020943,"domain_scores_codex":[0.9968522,0.0006928828,0.0008992606,0.0006303023,0.00006090451,0.0008644568],"domain_scores_gemma":[0.9985061,0.0002082561,0.0003734744,0.000698628,0.0001840088,0.00002949598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004752245,0.0000759652,0.001627275,0.00002077527,0.0002235885,0.00001344069,0.003143323,0.000003286432,0.9676053,0.005343611,0.0001292949,0.02133891],"study_design_scores_gemma":[0.002735433,0.001110509,0.1782601,0.0000794646,0.00005066806,0.0001769857,0.0004120997,0.0001006383,0.8048907,0.005623979,0.006027265,0.0005321395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938217,0.002992589,0.0001665444,0.0002920768,0.0007088645,0.0004966044,0.00001060398,0.0002041014,0.001306862],"genre_scores_gemma":[0.9984257,0.000269766,0.00005379226,0.00009066452,0.0001433531,0.00007382426,0.0004162706,0.00004938315,0.0004772986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1766329,"threshold_uncertainty_score":0.9998034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02089079123228367,"score_gpt":0.2435577486334844,"score_spread":0.2226669574012007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}