{"id":"W2885251054","doi":"10.1080/15548627.2018.1447290","title":"Importance of TFEB acetylation in control of its transcriptional activity and lysosomal function in response to histone deacetylase inhibitors","year":2018,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Medical Research Council","keywords":"TFEB; Acetylation; Biology; Autophagy; Histone deacetylase; mTORC1; Cell biology; HDAC4; Histone; Transcriptional regulation; Biochemistry; PI3K/AKT/mTOR pathway; Cancer research; Transcription factor; Signal transduction; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004058782,0.0001124572,0.0003100726,0.000268233,0.0000197218,0.000002158114,0.00003602483,0.00009051112,0.0001033677],"category_scores_gemma":[0.0001528545,0.0001124529,0.00005236826,0.0002831107,0.00009666271,0.0001392857,0.00000855162,0.00009817636,0.000004968331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009775877,"about_ca_system_score_gemma":0.0001452709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000799442,"about_ca_topic_score_gemma":0.00013413,"domain_scores_codex":[0.9989591,0.000113008,0.0003471449,0.0002203113,0.0002077782,0.0001526624],"domain_scores_gemma":[0.9994339,0.00008867624,0.0001174199,0.0001580446,0.000115216,0.00008670257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01815367,0.0003459858,0.01763728,0.00005798954,0.00002846267,0.00001712364,0.0006461971,0.00001934984,0.958069,0.000254609,0.0000211948,0.004749138],"study_design_scores_gemma":[0.00408948,0.0007674995,0.7441209,0.00008126446,0.00002506966,0.000005198482,0.0000271154,0.0006241337,0.2500246,0.00007693903,0.00009349662,0.0000642507],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975849,0.0008500271,0.0003841676,0.0005108225,0.0001243412,0.0004442459,0.00002046822,0.00001651421,0.00006454422],"genre_scores_gemma":[0.999358,0.00002082706,0.00007461978,0.0003029509,0.00007930164,0.00002544309,0.00000485507,0.00001248532,0.0001215245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7264836,"threshold_uncertainty_score":0.4585698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01185836412977876,"score_gpt":0.284626801359642,"score_spread":0.2727684372298633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}