{"id":"W2885253203","doi":"10.1080/15548627.2018.1505154","title":"MFN2 retrotranslocation boosts mitophagy by uncoupling mitochondria from the ER","year":2018,"lang":"en","type":"letter","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research","keywords":"Mitophagy; Biology; MFN2; Mitochondrion; Cell biology; Autophagy; Uncoupling protein; PINK1; mitochondrial fusion; Genetics; Biochemistry; Mitochondrial DNA; Apoptosis; Gene; Brown adipose tissue","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002905841,0.0003562358,0.000509141,0.0002721323,0.00060695,0.0005893256,0.0003133281,0.004179501,0.002786398],"category_scores_gemma":[0.001635277,0.0001014847,0.0003100614,0.0001419505,0.0004893697,0.000525385,0.0002812733,0.003057712,0.001952068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008889604,"about_ca_system_score_gemma":0.0002894052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003120935,"about_ca_topic_score_gemma":0.0004504976,"domain_scores_codex":[0.9998199,0.00005475593,0.00001763525,0.00001787967,0.00005054041,0.00003925745],"domain_scores_gemma":[0.999594,0.0001638964,0.0000425703,0.00003951143,0.00009261957,0.00006750212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002328219,0.0006269221,0.008360206,0.0007506007,0.00008093783,0.2580469,0.0005294489,0.000741516,0.04341166,0.01740273,0.489318,0.1784028],"study_design_scores_gemma":[0.001155451,0.001216144,0.01078298,0.0003819315,0.00008954701,0.2234028,0.0004195386,0.006690414,0.03640414,0.0175568,0.7018245,0.00007577292],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2147294,0.0470634,0.005951275,0.6132453,0.03547994,0.0002417268,0.0002666072,0.001301986,0.0817203],"genre_scores_gemma":[0.7320498,0.01937939,0.00375803,0.1396606,0.05731582,0.0002069996,0.0002235486,0.00008915941,0.04731667],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004179501,"threshold_uncertainty_score":0.009321451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01378951560133185,"score_gpt":0.2614072948838443,"score_spread":0.2476177792825125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}