{"id":"W2885253203","doi":"10.1080/15548627.2018.1505154","title":"MFN2 retrotranslocation boosts mitophagy by uncoupling mitochondria from the ER","year":2018,"lang":"en","type":"letter","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research","keywords":"Mitophagy; Biology; MFN2; Mitochondrion; Cell biology; Autophagy; Uncoupling protein; PINK1; mitochondrial fusion; Genetics; Biochemistry; Mitochondrial DNA; Apoptosis; Gene; Brown adipose tissue","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002015923,0.0007907611,0.0009154274,0.0001211754,0.0003264882,0.0001257673,0.000682146,0.001569349,0.003417838],"category_scores_gemma":[0.0001064335,0.00057366,0.0005559158,0.0003383135,0.0003511918,0.0001483774,0.00007391536,0.002199632,0.001522563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002219732,"about_ca_system_score_gemma":0.0003926829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005173101,"about_ca_topic_score_gemma":0.00001295091,"domain_scores_codex":[0.9960521,0.0001759869,0.0007673005,0.001121526,0.00105513,0.0008279183],"domain_scores_gemma":[0.9970206,0.0004710785,0.0003936424,0.001657568,0.0002624624,0.0001946461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001428707,0.00009470037,0.0001284739,0.00007833129,0.0006603064,0.0004032149,0.000233712,5.501374e-7,0.009750168,0.000006170222,0.985741,0.00276053],"study_design_scores_gemma":[0.00187188,0.0002649965,0.002012292,0.0004030241,0.0006922776,0.00003815565,0.00002101045,0.0002306263,0.04224518,0.0009661297,0.9506558,0.0005986981],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1154487,0.04886385,0.001877768,0.8147379,0.008876541,0.003847099,0.001133703,0.00108569,0.004128695],"genre_scores_gemma":[0.02801085,0.0007364617,0.0005152709,0.9075367,0.03255621,0.0002991581,0.006959538,0.0003589475,0.02302687],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.09279877,"threshold_uncertainty_score":0.9997268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01378951560133185,"score_gpt":0.2614072948838443,"score_spread":0.2476177792825125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}