{"id":"W2885257451","doi":"10.1158/1538-7445.am2018-1995","title":"Abstract 1995: PTHrP drives tumor initiation signaling pathways in the PyMT model of breast cancer progression","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Bone health and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Cancer research; Stromal cell; Tumor progression; Breast cancer; Cancer; Mammary tumor; PI3K/AKT/mTOR pathway; Wnt signaling pathway; Signal transduction; Biology; Endocrinology; Internal medicine; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001591547,0.0003578147,0.0003564551,0.0007466445,0.0003303961,0.0004544444,0.0002375748,0.0003446805,0.003024568],"category_scores_gemma":[0.0001246364,0.000161691,0.0003636315,0.0005538379,0.0003316285,0.0002225687,0.0003204757,0.0009822601,0.0007675042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005056973,"about_ca_system_score_gemma":0.0002908757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143385,"about_ca_topic_score_gemma":0.00107235,"domain_scores_codex":[0.9996489,0.0000278331,0.00002948262,0.00006789567,0.0001550263,0.00007088503],"domain_scores_gemma":[0.9998398,0.00001665487,0.00005901726,0.00001679299,0.00001762455,0.00005011769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002420769,0.0000410421,0.0003747609,0.0000301897,0.000005928451,0.00005490663,0.00001425023,0.00008913985,0.9976282,0.00009695852,0.0001053704,0.001317223],"study_design_scores_gemma":[0.00003592995,0.0003373457,0.009427829,0.000007579473,0.00002341972,0.0003605513,0.00005195362,0.001814823,0.9839941,0.0001199874,0.003819378,0.000007104621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872777,0.0009506982,0.004361699,0.0002640802,0.00004728903,0.00007604472,0.004761953,0.0002716452,0.001988715],"genre_scores_gemma":[0.9816629,0.0007099709,0.005133078,0.00009193198,0.00001417603,0.0001854295,0.00416903,0.0000610529,0.007972402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003024568,"threshold_uncertainty_score":0.01011825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1806569981756881,"score_gpt":0.4738079915336838,"score_spread":0.2931509933579957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}