{"id":"W2885263529","doi":"10.1038/s41467-018-05482-0","title":"Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":285,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"U.S. Department of Health and Human Services; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Takeda Pharmaceuticals U.S.A.; University of Pennsylvania; Burroughs Wellcome Fund","keywords":"Virology; Hemagglutinin (influenza); Virus; Antigenic drift; Influenza A virus; Biology; Immunization; Influenza vaccine; Heterologous; Antibody; H5N1 genetic structure; Orthomyxoviridae; Gene; Immunology; Medicine; Infectious disease (medical specialty); Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001587296,0.0004048154,0.0002188864,0.0001618245,0.0001009141,0.0001705279,0.0001476633,0.0003185138,0.0008044814],"category_scores_gemma":[0.0001364923,0.0001049175,0.0001789421,0.00006755133,0.0002193051,0.0001521093,0.0001224063,0.0004872341,0.0003137791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002829584,"about_ca_system_score_gemma":0.0001534658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004282705,"about_ca_topic_score_gemma":0.0007751549,"domain_scores_codex":[0.9998847,0.00001814738,0.00000788088,0.00002564,0.00003043467,0.00003316368],"domain_scores_gemma":[0.9999115,0.00002232253,0.00002348358,0.00001072545,0.0000153985,0.00001653932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000485413,0.00003500906,0.00008743952,0.00001261374,0.00000205013,0.00001505662,0.000005853894,0.0000435829,0.9990463,0.00002641131,0.00001281184,0.0006643705],"study_design_scores_gemma":[0.00001989576,0.001305757,0.001687016,0.000003949925,0.00001424549,0.0001129167,0.00001060121,0.0005740217,0.9955131,0.00002650124,0.0007297453,0.000002109727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954675,0.0004041054,0.002246396,0.00005527037,0.00002735695,0.00004869338,0.00007172886,0.00005491561,0.001624004],"genre_scores_gemma":[0.9952206,0.0004267601,0.001949464,0.00007100862,0.00002191942,0.00002814472,0.0002350845,0.00001736426,0.002029686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008044814,"threshold_uncertainty_score":0.002691269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1062330333315361,"score_gpt":0.4232881667506614,"score_spread":0.3170551334191253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}