{"id":"W2885263529","doi":"10.1038/s41467-018-05482-0","title":"Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":285,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"U.S. Department of Health and Human Services; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Takeda Pharmaceuticals U.S.A.; University of Pennsylvania; Burroughs Wellcome Fund","keywords":"Virology; Hemagglutinin (influenza); Virus; Antigenic drift; Influenza A virus; Biology; Immunization; Influenza vaccine; Heterologous; Antibody; H5N1 genetic structure; Orthomyxoviridae; Gene; Immunology; Medicine; Infectious disease (medical specialty); Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005353103,0.000303741,0.0004467126,0.0004035107,0.001297358,0.00009378573,0.001147109,0.000423406,0.0001288561],"category_scores_gemma":[0.001381071,0.0002742791,0.0001398226,0.001076788,0.001192929,0.0002871009,0.001121574,0.001705663,0.0005400598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002050891,"about_ca_system_score_gemma":0.000174185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001102731,"about_ca_topic_score_gemma":0.0003728238,"domain_scores_codex":[0.9976796,0.0002442186,0.0005777649,0.0003673889,0.0006062,0.0005248323],"domain_scores_gemma":[0.9939371,0.0004388693,0.0002056558,0.003470027,0.001778723,0.0001696614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002005583,0.00288047,0.06987698,0.0002853833,0.001801828,0.00003274396,0.01512475,0.0000312788,0.499004,0.1583093,0.2080711,0.04257652],"study_design_scores_gemma":[0.001975679,0.0002991051,0.1593941,0.0002465339,0.0000992093,0.00002693725,0.0006004563,0.0005550746,0.02333362,0.0004675958,0.8125756,0.0004260507],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7000862,0.1121252,0.000325895,0.01218449,0.0006587314,0.002568072,0.0002699428,0.0011185,0.1706629],"genre_scores_gemma":[0.9780921,0.009481871,0.008164427,0.003227215,0.0002974408,0.00007308494,0.0001565615,0.00006539377,0.000441844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6045045,"threshold_uncertainty_score":0.9999709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1062330333315361,"score_gpt":0.4232881667506614,"score_spread":0.3170551334191253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}