{"id":"W2885310075","doi":"10.1089/hum.2018.118","title":"New MiniPromoter Ple345 ( <i>NEFL</i> ) Drives Strong and Specific Expression in Retinal Ganglion Cells of Mouse and Primate Retina","year":2018,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; BC Children's Hospital; Centre Hospitalier de l’Université de Montréal; University of British Columbia","funders":"National Eye Institute; Oregon National Primate Research Center; National Institutes of Health","keywords":"Biology; Retina; Retinal ganglion cell; Genetic enhancement; Retinal; Neurodegeneration; Ganglion; Adeno-associated virus; Vectors in gene therapy; Neuroscience; Gene; Genetics; Pathology; Viral vector; Recombinant DNA; Vector (molecular biology); Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002239779,0.0003348262,0.0002421772,0.0002287382,0.0001850102,0.0002759676,0.0003058136,0.000308797,0.001159265],"category_scores_gemma":[0.0002108036,0.0001988072,0.0003553697,0.0001472415,0.0002486889,0.0002147597,0.0002774201,0.0006266895,0.000431272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000330768,"about_ca_system_score_gemma":0.0003074715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008487732,"about_ca_topic_score_gemma":0.002046478,"domain_scores_codex":[0.9997986,0.00001639311,0.00001941805,0.00007484417,0.00006636798,0.000024356],"domain_scores_gemma":[0.9998895,0.00002877139,0.00003532023,0.000012296,0.00001391463,0.00002016924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002575859,0.000008916611,0.0001382278,0.00002994813,0.00000233078,0.00002315364,0.00001054938,0.0002192669,0.9971693,0.0001053256,0.00005528128,0.002211801],"study_design_scores_gemma":[0.000009286679,0.0001283621,0.001606499,0.00001054278,0.00001557369,0.0001844846,0.0000154307,0.002482488,0.9896832,0.00006958636,0.005785192,0.000009312104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9245201,0.001601479,0.06419627,0.000293217,0.00005700578,0.0001869567,0.003019707,0.001405593,0.004719798],"genre_scores_gemma":[0.9031313,0.001441991,0.0831118,0.0002607088,0.00001226746,0.0002401062,0.00474193,0.0004054153,0.00665444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001159265,"threshold_uncertainty_score":0.003878057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01304664796662898,"score_gpt":0.2531650558713177,"score_spread":0.2401184079046887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}