{"id":"W2885310075","doi":"10.1089/hum.2018.118","title":"New MiniPromoter Ple345 ( <i>NEFL</i> ) Drives Strong and Specific Expression in Retinal Ganglion Cells of Mouse and Primate Retina","year":2018,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; BC Children's Hospital; Centre Hospitalier de l’Université de Montréal; University of British Columbia","funders":"National Eye Institute; Oregon National Primate Research Center; National Institutes of Health","keywords":"Biology; Retina; Retinal ganglion cell; Genetic enhancement; Retinal; Neurodegeneration; Ganglion; Adeno-associated virus; Vectors in gene therapy; Neuroscience; Gene; Genetics; Pathology; Viral vector; Recombinant DNA; Vector (molecular biology); Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117076,0.0001378663,0.0001335281,0.00005177231,0.0000565134,0.00001987917,0.00008831435,0.00008389025,0.00005546975],"category_scores_gemma":[0.000002261414,0.0001220608,0.00002439472,0.00004125569,0.0001291424,0.000005892467,0.00006363609,0.00004456992,0.000001703075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003969994,"about_ca_system_score_gemma":0.00001831015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008723856,"about_ca_topic_score_gemma":0.00001266443,"domain_scores_codex":[0.9992255,0.00004351162,0.0001864376,0.0002910378,0.00008688088,0.0001666194],"domain_scores_gemma":[0.9996539,0.000003947118,0.00008046957,0.0001758939,0.00003043699,0.00005534866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002940983,0.00002886397,0.004737474,0.000009943347,0.000006717068,0.000001624385,0.0005235071,3.692543e-7,0.9898674,0.00001448977,0.001360578,0.003154954],"study_design_scores_gemma":[0.001111073,0.0005552174,0.01156146,0.00002731188,0.000001784359,0.00000385256,0.00009650529,0.00000304939,0.9812334,0.0001144133,0.00514397,0.0001479214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968708,0.001911475,0.0002146422,0.00002919346,0.00003633536,0.0001593245,0.000002480909,0.00000586054,0.0007699585],"genre_scores_gemma":[0.9912884,0.00311093,0.004557528,0.00006090987,0.0001552043,0.000004348021,0.00003853009,0.00002281891,0.0007613788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008633941,"threshold_uncertainty_score":0.4977494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01304664796662898,"score_gpt":0.2531650558713177,"score_spread":0.2401184079046887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}