{"id":"W2885322595","doi":"10.1371/journal.pcbi.1006349","title":"Discerning evolutionary trends in post-translational modification and the effect of intrinsic disorder: Analysis of methylation, acetylation and ubiquitination sites in human proteins","year":2018,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Posttranslational modification; Acetylation; Ubiquitin; Methylation; Computational biology; Biology; Genetics; Chemistry; Bioinformatics; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004405559,0.00009351841,0.0002119342,0.000425206,0.00006545689,0.000005064228,0.00005866013,0.00009583709,0.00001572471],"category_scores_gemma":[0.0001351551,0.00007429701,0.00004511861,0.0004268229,0.0003538939,0.00001133095,0.00003922284,0.0000583742,1.821303e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000922055,"about_ca_system_score_gemma":0.00001890037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007929237,"about_ca_topic_score_gemma":0.0002830198,"domain_scores_codex":[0.9988908,0.0003795107,0.0003310407,0.0002230138,0.00009067389,0.00008501418],"domain_scores_gemma":[0.9993708,0.0001993512,0.0001865789,0.00007969468,0.0001485753,0.00001506769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006460156,0.00008272601,0.5863616,0.00004419383,0.0002662321,8.317955e-8,0.0008226633,0.007757374,0.3773727,0.01331567,0.000001549359,0.01332921],"study_design_scores_gemma":[0.001695488,0.0005749995,0.8981591,0.00001285782,0.00009249556,0.000001076994,0.00003086151,0.06698222,0.02927814,0.003070584,0.000009662161,0.00009245382],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951757,0.0004060545,0.003632932,0.0003404199,0.000007611622,0.0002897673,0.00005657008,0.000003888599,0.00008705459],"genre_scores_gemma":[0.9969002,0.00001316391,0.0007145682,0.00001482936,0.00003597726,0.00004890798,0.00226221,0.000005209422,0.000004954519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3480946,"threshold_uncertainty_score":0.3029744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01188306553164732,"score_gpt":0.2805485457641766,"score_spread":0.2686654802325293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}