{"id":"W2885355806","doi":"10.1016/j.stemcr.2018.07.003","title":"High-Resolution Single-Cell DNA Methylation Measurements Reveal Epigenetically Distinct Hematopoietic Stem Cell Subpopulations","year":2018,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Terry Fox Research Institute; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Division of Materials Research; Canadian Cancer Society Research Institute; Canada Foundation for Innovation; Genome British Columbia; CIHR Skin Research Training Centre; Canadian Cancer Society; Michael Smith Health Research BC; Terry Fox Research Institute; California HIV/AIDS Research Program; Western Canada Research Grid; Lotte and John Hecht Memorial Foundation; Compute Canada; Canadian Institutes of Health Research; Genome Canada","keywords":"Biology; DNA methylation; Epigenetics; Stem cell; Methylation; Haematopoiesis; Bisulfite sequencing; CpG site; Illumina Methylation Assay; Genetics; Computational biology; Cell biology; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000364197,0.0001869386,0.0003017339,0.0004759975,0.0002342026,0.0004124313,0.0002148504,0.0002553412,0.00057513],"category_scores_gemma":[0.0006698671,0.0001919883,0.0002039858,0.0003676388,0.0002445152,0.0002114131,0.000369523,0.0004231104,0.0002049559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002024485,"about_ca_system_score_gemma":0.0001829966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007009866,"about_ca_topic_score_gemma":0.002133747,"domain_scores_codex":[0.9998274,0.00001977617,0.00001080479,0.00006885435,0.00005725367,0.00001587983],"domain_scores_gemma":[0.999772,0.00008449794,0.00003644266,0.00004024873,0.000041314,0.00002540541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004872137,0.000006000994,0.004086728,0.00002074916,0.00001582165,0.00001475354,0.00006363026,0.0007372021,0.9896248,0.0001773278,0.0000264514,0.005177768],"study_design_scores_gemma":[0.000008689263,0.00008390101,0.04400355,0.000003812936,0.00003352494,0.0001489093,0.00007123289,0.01694027,0.9367462,0.0009182711,0.001025477,0.00001618269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9504741,0.0002190367,0.04760731,0.00004508445,0.000004487305,0.00002477063,0.0008601184,0.0001963944,0.0005686307],"genre_scores_gemma":[0.9589278,0.0001496474,0.03928927,0.00003289029,0.000003155687,0.00004202529,0.0009901002,0.00005437699,0.0005107551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007009866,"threshold_uncertainty_score":0.001926064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03022714215867381,"score_gpt":0.2512564621587957,"score_spread":0.2210293200001218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}