{"id":"W2885431388","doi":"10.1158/1538-7445.am2018-1759","title":"Abstract 1759: AVID200, a highly potent TGF-beta trap, exhibits optimal isoform selectivity for enhancing anti-tumor T-cell activity, without promoting metastasis or cardiotoxicity","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; National Research Council Canada","funders":"","keywords":"Cancer research; Ectodomain; Metastasis; TGF beta signaling pathway; Antibody; Cancer cell; Cancer; Tumor microenvironment; T cell; Biology; Transforming growth factor; Transforming growth factor beta; Immune system; Immunology; Medicine; Receptor; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001540865,0.0003336708,0.0001585242,0.0001684085,0.0001034013,0.0001927081,0.0002364481,0.0003506085,0.002562384],"category_scores_gemma":[0.00007439345,0.00008462137,0.0001309931,0.0001131847,0.000107975,0.0001435025,0.0001111033,0.0003905644,0.0005923508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001899656,"about_ca_system_score_gemma":0.0001412776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005467635,"about_ca_topic_score_gemma":0.0007553725,"domain_scores_codex":[0.9999081,0.00001253308,0.000005561343,0.00002198552,0.00003044554,0.00002139825],"domain_scores_gemma":[0.9999485,0.00001080537,0.00001366566,0.000003877775,0.000009097503,0.00001403731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001153953,0.00003524156,0.00005722164,0.00002731799,0.000003316243,0.00002683037,0.000005972483,0.00006346937,0.9976693,0.00005186779,0.00009130032,0.001852791],"study_design_scores_gemma":[0.00004223722,0.000666104,0.0007213647,0.00000350753,0.00001119459,0.000481368,0.000004507237,0.0006496949,0.9946072,0.00001517236,0.002794906,0.000002824643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856947,0.002345396,0.007553018,0.0001484111,0.00003540533,0.00005767919,0.0004740398,0.0001473577,0.003544085],"genre_scores_gemma":[0.9877386,0.0005988912,0.005763785,0.0001022188,0.00001871184,0.00003017003,0.0009154666,0.00003154455,0.0048007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002562384,"threshold_uncertainty_score":0.008571982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09743525780904905,"score_gpt":0.4124802058420965,"score_spread":0.3150449480330475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}