{"id":"W2885488593","doi":"10.1038/s41396-018-0254-2","title":"Extrachromosomal circular elements targeted by CRISPR-Cas in <i>Dehalococcoides mccartyi</i> are linked to mobilization of reductive dehalogenase genes","year":2018,"lang":"en","type":"article","venue":"The ISME Journal","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Strategic Environmental Research and Development Program; Ontario Genomics Institute; Government of Ontario; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Government of Canada; U.S. Department of Defense","keywords":"Biology; Genome; Extrachromosomal DNA; Prophage; CRISPR; Dehalogenase; Genetics; Genomic island; Metagenomics; Horizontal gene transfer; Gene; Bacteriophage; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001393186,0.0003400197,0.0003388902,0.0002874279,0.0001979857,0.0004093971,0.0003055673,0.000371151,0.0006385914],"category_scores_gemma":[0.0003680812,0.0002192239,0.0003599874,0.0003206912,0.0002145379,0.0001578311,0.000478378,0.0006613163,0.0003176977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005205359,"about_ca_system_score_gemma":0.0003537039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005880589,"about_ca_topic_score_gemma":0.007284266,"domain_scores_codex":[0.9997476,0.00001425162,0.00003267737,0.00008188988,0.000072141,0.00005150295],"domain_scores_gemma":[0.9997231,0.00004839797,0.0001207111,0.00003988473,0.00002380048,0.00004398662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003953592,0.00001221811,0.0008642441,0.00002499063,0.000005069891,0.00008618047,0.00002822529,0.00009536261,0.9976091,0.00002951785,0.00002318151,0.001182331],"study_design_scores_gemma":[0.00001390692,0.0001734072,0.04934676,0.00001531375,0.00002721345,0.0005621847,0.0001312444,0.001611909,0.94459,0.00003963194,0.003464757,0.00002361812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953994,0.0002844515,0.002212377,0.00005100172,0.0000165093,0.00003937757,0.00108431,0.0001162079,0.0007964025],"genre_scores_gemma":[0.9894872,0.0002388607,0.005351468,0.00008062429,0.000005415344,0.00005663999,0.002306423,0.00006612698,0.002407196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005880589,"threshold_uncertainty_score":0.0116927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009534215766656716,"score_gpt":0.2539120589980622,"score_spread":0.2443778432314055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}