{"id":"W2885490407","doi":"10.1158/1538-7445.am2018-ct001","title":"Abstract CT001: Pembrolizumab versus placebo after complete resection of high-risk stage III melanoma: Efficacy and safety results from the EORTC 1325-MG/Keynote 054 double-blinded phase III trial","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Pembrolizumab; Internal medicine; Population; Hazard ratio; Ipilimumab; Melanoma; Interim analysis; Surgery; Placebo; Oncology; Nivolumab; Gastroenterology; Clinical trial; Cancer; Immunotherapy; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001541522,0.001538934,0.001679379,0.0003626286,0.0003382239,0.001060644,0.000796185,0.001441831,0.008684511],"category_scores_gemma":[0.001811565,0.0003897445,0.001617777,0.0003350411,0.0009674213,0.0007711272,0.0002649998,0.00303883,0.001500363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008122234,"about_ca_system_score_gemma":0.001339652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008424348,"about_ca_topic_score_gemma":0.001478859,"domain_scores_codex":[0.9995351,0.0002689459,0.00003573086,0.00007406507,0.00004203777,0.00004406192],"domain_scores_gemma":[0.998828,0.000378836,0.0003029893,0.00006880462,0.00007053878,0.0003508383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9731741,0.00517377,0.0004057015,0.0005761635,0.0006136046,0.00004069859,0.00002627713,0.0003134408,0.00503802,0.00008835635,0.001603522,0.01294626],"study_design_scores_gemma":[0.8953375,0.0997711,0.001954854,0.00005597132,0.0004032591,0.00006282501,0.00001367,0.0005127398,0.001125122,0.000124897,0.0006250042,0.00001301485],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788294,0.006757749,0.001140806,0.0009511611,0.0006670399,0.003866784,0.003092803,0.0002394643,0.004454858],"genre_scores_gemma":[0.9832858,0.002805121,0.001107844,0.001117118,0.0005068001,0.003126231,0.002715699,0.00003173067,0.005303646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008684511,"threshold_uncertainty_score":0.02905262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1237631301406919,"score_gpt":0.4187451378439692,"score_spread":0.2949820077032773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}