{"id":"W2885545279","doi":"10.1158/1538-7445.am2018-2709","title":"Abstract 2709: TTI-622 (SIRPα-IgG4 Fc), a CD47-blocking innate immune checkpoint inhibitor, suppresses tumor growth and demonstrates enhanced efficacy in combination with antitumor antibodies in both hematologic and solid tumor models","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Trillium Therapeutics (Canada)","funders":"","keywords":"CD47; Phagocytosis; Cancer research; In vivo; Daratumumab; Antibody; Macrophage; Immune system; In vitro; Immunology; Chemistry; Monoclonal antibody; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009287714,0.0002885081,0.000594367,0.000577121,0.0003575224,0.0001109998,0.0002273071,0.0001541055,0.00004929875],"category_scores_gemma":[0.0001750318,0.0002379632,0.00003730486,0.0005397347,0.001267348,0.0005618763,0.0002280693,0.0006669141,0.0000107635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001184215,"about_ca_system_score_gemma":0.000226039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001294045,"about_ca_topic_score_gemma":0.000692135,"domain_scores_codex":[0.9975806,0.0003029545,0.0005846934,0.0006157742,0.0001465823,0.0007694338],"domain_scores_gemma":[0.9989728,0.000270582,0.0001969718,0.000251558,0.0002641987,0.00004387104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008660847,0.0003423504,0.009495072,0.0002631499,0.0000536851,0.00003692453,0.001296451,0.00002903244,0.986332,0.0004696053,0.00003114812,0.0007844784],"study_design_scores_gemma":[0.003265493,0.0004625054,0.1978859,0.0009725569,0.000009342432,0.00007715029,0.0005532652,0.0002122164,0.7955377,0.0007593466,0.00001559631,0.0002489088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874817,0.01101864,0.00002329703,0.0003136728,0.0001145661,0.0007229717,0.00001735646,0.00004188228,0.0002659813],"genre_scores_gemma":[0.9982091,0.001442979,0.00005563507,0.0000231529,0.00002931037,0.000134863,0.00003656832,0.00003118323,0.00003718794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1907943,"threshold_uncertainty_score":0.9703858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03808320839186958,"score_gpt":0.336023819973344,"score_spread":0.2979406115814744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}