{"id":"W2885545279","doi":"10.1158/1538-7445.am2018-2709","title":"Abstract 2709: TTI-622 (SIRPα-IgG4 Fc), a CD47-blocking innate immune checkpoint inhibitor, suppresses tumor growth and demonstrates enhanced efficacy in combination with antitumor antibodies in both hematologic and solid tumor models","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Trillium Therapeutics (Canada)","funders":"","keywords":"CD47; Phagocytosis; Cancer research; In vivo; Daratumumab; Antibody; Macrophage; Immune system; In vitro; Immunology; Chemistry; Monoclonal antibody; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001715145,0.0007812268,0.0007197356,0.0003973303,0.000143261,0.0002844301,0.0003130868,0.0003921214,0.002824767],"category_scores_gemma":[0.00007405039,0.0001452258,0.0003460307,0.0002718859,0.0002031287,0.0001932202,0.0001548031,0.00109757,0.0008736341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003378998,"about_ca_system_score_gemma":0.0003753205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001282868,"about_ca_topic_score_gemma":0.001434683,"domain_scores_codex":[0.999826,0.00002583384,0.00001293342,0.00002373556,0.00005960913,0.00005185831],"domain_scores_gemma":[0.9999369,0.000005066937,0.00001383996,0.000006507956,0.000007053381,0.00003059726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002383786,0.001214127,0.000205989,0.0001179151,0.00005974201,0.0001224367,0.00001364854,0.0003263401,0.9813762,0.0001443638,0.001261393,0.012774],"study_design_scores_gemma":[0.0009302411,0.0103963,0.003117786,0.00001050069,0.0001085362,0.0005738728,0.00001551995,0.002234951,0.9745712,0.00004125727,0.007989611,0.00001033576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848861,0.005045978,0.00249432,0.0002955944,0.0002592981,0.0001580748,0.0008975,0.0004719115,0.005491168],"genre_scores_gemma":[0.9870909,0.00182551,0.001548296,0.0001341901,0.00007875029,0.0001157531,0.001719941,0.00005091847,0.007435542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002824767,"threshold_uncertainty_score":0.00944972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03808320839186958,"score_gpt":0.336023819973344,"score_spread":0.2979406115814744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}