{"id":"W2885564300","doi":"10.1111/jcmm.13821","title":"Sirtuin3 protects aged human mesenchymal stem cells against oxidative stress and enhances efficacy of cell therapy for ischaemic heart diseases","year":2018,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"Natural Science Foundation of Heilongjiang Province; National Natural Science Foundation of China","keywords":"Oxidative stress; SIRT3; Mesenchymal stem cell; Transplantation; Superoxide dismutase; Antioxidant; Stem cell; Catalase; Cell therapy; Stem-cell therapy; Cancer research; Viability assay; Transfection; Pharmacology; Medicine; Cell; Chemistry; Biology; Cell biology; Endocrinology; Internal medicine; Biochemistry; Enzyme; Sirtuin; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001860233,0.000266341,0.0004263979,0.0003114648,0.0001494265,0.0002270908,0.0001806076,0.0002788802,0.001416096],"category_scores_gemma":[0.00008376368,0.00008549769,0.0003902239,0.0002119793,0.0001660774,0.0002209849,0.0002160716,0.0004723798,0.0003548448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001568824,"about_ca_system_score_gemma":0.0002009612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004893137,"about_ca_topic_score_gemma":0.001006327,"domain_scores_codex":[0.9999045,0.00001611105,0.00001235169,0.00001675006,0.000030305,0.00001997698],"domain_scores_gemma":[0.9999526,0.000003252027,0.00001088955,0.000005870234,0.00001114232,0.00001637735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006293898,0.0001861649,0.0008294735,0.0003680298,0.00006051717,0.0001167493,0.00005363969,0.0001786031,0.9750566,0.0003082371,0.0004473678,0.02176514],"study_design_scores_gemma":[0.0002228303,0.002419635,0.02344873,0.00007890619,0.0002999133,0.0007057894,0.0001128643,0.001539088,0.9360019,0.0004098265,0.03473509,0.00002544679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9408413,0.04410243,0.009047675,0.0004869784,0.000380142,0.00009076328,0.0008029598,0.0003277619,0.003919956],"genre_scores_gemma":[0.9837701,0.009472931,0.002664588,0.000242967,0.00005898064,0.00004471901,0.0009439243,0.00002636392,0.00277527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001416096,"threshold_uncertainty_score":0.004737258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315229454887428,"score_gpt":0.2827493262886538,"score_spread":0.2695970317397796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}