{"id":"W2885588864","doi":"10.1016/s0140-6736(18)31773-2","title":"Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial","year":2018,"lang":"en","type":"article","venue":"The Lancet","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":804,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University; LMC Diabetes & Endocrinology (Canada)","funders":"Novo Nordisk","keywords":"Medicine; Semaglutide; Liraglutide; Placebo; Clinical endpoint; Dose-ranging study; Weight loss; Randomized controlled trial; Intention-to-treat analysis; Internal medicine; Body mass index; Obesity; Type 2 diabetes; Diabetes mellitus; Double blind; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00244162,0.002983442,0.00601705,0.0007484536,0.0005955211,0.001706581,0.001304227,0.003522469,0.008075811],"category_scores_gemma":[0.002682982,0.001433098,0.003427149,0.0005772241,0.002043957,0.002065344,0.0006434302,0.004807608,0.001489637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009634821,"about_ca_system_score_gemma":0.0009394438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009681281,"about_ca_topic_score_gemma":0.001579742,"domain_scores_codex":[0.998975,0.000527663,0.00008168338,0.0002113936,0.00008165588,0.0001225112],"domain_scores_gemma":[0.9989136,0.0003846271,0.0002566848,0.00009808968,0.00006661283,0.0002804013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9939269,0.001276323,0.0001464344,0.000308045,0.0005610826,0.00001423549,0.00002093262,0.00008251714,0.0007488949,0.00003076957,0.000207976,0.002675845],"study_design_scores_gemma":[0.9798793,0.01873834,0.0005065501,0.00001653935,0.0003791553,0.00001206647,0.000009954651,0.0001412139,0.0001118707,0.00005923298,0.0001354844,0.00001026332],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820138,0.0083747,0.0007854124,0.001149007,0.001157322,0.002626302,0.001234044,0.0002332203,0.00242616],"genre_scores_gemma":[0.9848874,0.003700945,0.001406319,0.001587136,0.0008499198,0.002954701,0.00112736,0.00005762475,0.003428627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008075811,"threshold_uncertainty_score":0.02701628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02126388715541555,"score_gpt":0.284934066006599,"score_spread":0.2636701788511835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}