{"id":"W2885610620","doi":"10.3390/molecules23081961","title":"A Three Component Synthetic Vaccine Containing a β-Mannan T-Cell Peptide Epitope and a β-Glucan Dendritic Cell Ligand","year":2018,"lang":"en","type":"article","venue":"Molecules","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Epitope; Conjugate; Chemistry; Peptide; Glycoconjugate; Mannan; Click chemistry; Conjugate vaccine; Biochemistry; Biology; Immune system; Antigen; Combinatorial chemistry; Immunogenicity; Polysaccharide; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001834933,0.0001993665,0.0001818872,0.00008344866,0.0001873277,0.00007588914,0.0001916127,0.0001145183,0.00005077276],"category_scores_gemma":[0.00006849372,0.0001879019,0.00006334324,0.00009119658,0.0001318057,0.000004594495,0.0002078389,0.0001185643,0.00006145971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001369198,"about_ca_system_score_gemma":0.00006200157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001308323,"about_ca_topic_score_gemma":0.0005115987,"domain_scores_codex":[0.9986929,0.0000605185,0.0002135173,0.0004537189,0.0001906476,0.0003886423],"domain_scores_gemma":[0.9992191,0.00001923031,0.00006163769,0.0003728892,0.0001416241,0.0001855151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00017957,0.00009452125,0.002146869,0.00004693379,0.00002037751,0.00002800506,0.0001062007,0.000004337197,0.9943612,0.0000828797,0.0009617339,0.001967402],"study_design_scores_gemma":[0.00167119,0.001354951,0.005389468,0.00005352808,0.00002397758,0.0000528909,0.0001603483,0.001135907,0.9640068,0.0001796833,0.02563245,0.0003387975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899817,0.001755088,0.003873694,0.0003547614,0.00006070499,0.0003347288,0.00001226149,0.00002051246,0.003606591],"genre_scores_gemma":[0.9975421,0.0001332464,0.00112773,0.000288541,0.0001693143,0.00003967862,0.00003808871,0.00003515698,0.0006261821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03035437,"threshold_uncertainty_score":0.7662416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055580776158026,"score_gpt":0.2480498781151139,"score_spread":0.2374940703535336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}