{"id":"W2885610620","doi":"10.3390/molecules23081961","title":"A Three Component Synthetic Vaccine Containing a β-Mannan T-Cell Peptide Epitope and a β-Glucan Dendritic Cell Ligand","year":2018,"lang":"en","type":"article","venue":"Molecules","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Epitope; Conjugate; Chemistry; Peptide; Glycoconjugate; Mannan; Click chemistry; Conjugate vaccine; Biochemistry; Biology; Immune system; Antigen; Combinatorial chemistry; Immunogenicity; Polysaccharide; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001381679,0.0004292048,0.0003043471,0.0002137025,0.0001326523,0.0002927364,0.0002867026,0.0003857213,0.000671307],"category_scores_gemma":[0.0001202114,0.0001633251,0.0002441062,0.0002250266,0.0001884333,0.0002509529,0.0002574506,0.0004815106,0.0003976323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003618842,"about_ca_system_score_gemma":0.0004362055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002352888,"about_ca_topic_score_gemma":0.0002289112,"domain_scores_codex":[0.9998926,0.00001804382,0.000009272427,0.00002525028,0.00002966158,0.000025151],"domain_scores_gemma":[0.9999452,0.000007063186,0.00001500267,0.000006927827,0.000007813269,0.00001791124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008433905,0.00005961833,0.00009858044,0.0000577411,0.000007343534,0.00005185073,0.00000987862,0.0005447027,0.9959412,0.0005667424,0.00005256811,0.002525596],"study_design_scores_gemma":[0.00005367364,0.001101972,0.0005614413,0.000009287705,0.00003129711,0.000301997,0.00001245953,0.002326357,0.9891773,0.0002395116,0.00617392,0.00001091002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9591699,0.001216619,0.03521658,0.0002063877,0.0001697218,0.0002702132,0.0005026207,0.0002308269,0.003017273],"genre_scores_gemma":[0.9704965,0.0006730852,0.02487818,0.0001375027,0.00001933064,0.0001335259,0.0006157938,0.00002866484,0.003017467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000671307,"threshold_uncertainty_score":0.002625704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055580776158026,"score_gpt":0.2480498781151139,"score_spread":0.2374940703535336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}