{"id":"W2885622469","doi":"10.3390/cancers10080264","title":"The SUMO System and TGFβ Signaling Interplay in Regulation of Epithelial-Mesenchymal Transition: Implications for Cancer Progression","year":2018,"lang":"en","type":"review","venue":"Cancers","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; Alberta Cancer Foundation","keywords":"Epithelial–mesenchymal transition; SUMO protein; Interactome; Metastasis; Transforming growth factor; Cell biology; Cancer; Biology; Ubiquitin; Tumor progression; Cancer research; Cancer cell; Transforming growth factor beta; SMAD; Chemistry; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003659005,0.0001570279,0.0003608782,0.0000376205,0.0001068453,0.00001782895,0.000142173,0.0001985317,0.000003030727],"category_scores_gemma":[0.00002474597,0.0001074557,0.0001449835,0.00008786034,0.0001169054,0.000002694471,0.00002587225,0.00006760823,3.758646e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000178825,"about_ca_system_score_gemma":0.0005232941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002603259,"about_ca_topic_score_gemma":0.00008813424,"domain_scores_codex":[0.9990017,0.0001042094,0.0003983497,0.0002875825,0.00005675135,0.0001513692],"domain_scores_gemma":[0.9992697,0.00004716464,0.0003076217,0.0002373772,0.0001024329,0.00003570134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009309487,0.000006334896,0.00001294251,0.01126308,0.0001158095,1.719209e-7,0.000195862,0.00003191528,0.01100785,0.0004498998,0.0005292746,0.9762937],"study_design_scores_gemma":[0.0002651319,0.0001789397,0.00001550009,0.01007772,0.0001419442,0.00001090505,0.00007912557,0.00008591812,0.01062313,0.00004638225,0.9782651,0.0002101869],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001250408,0.9961711,0.0005983329,0.000051077,0.0001992155,0.001216629,0.0004148601,0.000005512097,0.00009290522],"genre_scores_gemma":[0.02353553,0.973974,0.0001974549,0.00001210016,0.0004795193,0.001457711,0.0002532965,0.00002869441,0.00006168857],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9777358,"threshold_uncertainty_score":0.4381918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03146211997741679,"score_gpt":0.3499147674476487,"score_spread":0.3184526474702319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}