{"id":"W2885623479","doi":"10.1139/bcb-2018-0158","title":"Molecular modeling and inhibitor docking analysis of the Na+/H+ exchanger isoform one","year":2018,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Extracellular; Antiporter; Transmembrane protein; Intracellular; Amino acid; Intracellular pH; Gene isoform; Transmembrane domain; Biochemistry; Sodium–hydrogen antiporter; Chemistry; Biophysics; Sodium; Membrane; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001878023,0.0002484312,0.0003070058,0.0000714863,0.0001668154,0.00001633102,0.0001850594,0.0004674684,0.00004152507],"category_scores_gemma":[0.00002121933,0.0002038601,0.000180271,0.0002614047,0.0003656838,0.000006180403,0.0001427716,0.0001154417,0.00000104633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001172904,"about_ca_system_score_gemma":0.00004487626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002948039,"about_ca_topic_score_gemma":0.000004403464,"domain_scores_codex":[0.9986452,0.00004562182,0.0003367919,0.0005456322,0.0001100884,0.0003166622],"domain_scores_gemma":[0.9992087,0.00001105101,0.0001330745,0.0004045443,0.000146958,0.00009567854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000108953,0.00005844989,0.003163456,0.00008632986,0.0002867751,8.394485e-7,0.0002582843,0.003080939,0.9918679,0.00003021049,0.00003463855,0.001023226],"study_design_scores_gemma":[0.0004610457,0.0001443097,0.0001822643,0.00002538663,0.0003560351,0.000004709515,0.0003428088,0.06066178,0.9364164,0.00005945191,0.001085561,0.0002602582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952994,0.001914014,0.001849191,0.00009990259,0.00004461048,0.0001268139,0.00005843112,0.00001164441,0.0005959778],"genre_scores_gemma":[0.998471,0.000239064,0.0001443713,0.0001645398,0.0003331105,0.00001315201,0.0003827357,0.00001860127,0.0002334559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05758084,"threshold_uncertainty_score":0.8313172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009395164779082558,"score_gpt":0.2166620119099716,"score_spread":0.207266847130889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}