{"id":"W2885626840","doi":"10.1101/389122","title":"Receptor Mediated Delivery of Cas9-Nanobody Induces Cisplatin Synthetic Dose Sensitivity","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; William Osler Health System","funders":"","keywords":"Ribonucleoprotein; Transfection; Cas9; CRISPR; Cisplatin; Chemistry; Cell biology; Internalization; A549 cell; Molecular biology; Cancer research; Cell; Biology; RNA; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001483317,0.0002451705,0.0003403597,0.0002125715,0.0001244486,0.0002906856,0.0002560323,0.0004135818,0.001947651],"category_scores_gemma":[0.0001549425,0.0001412913,0.0002785691,0.0001178191,0.000236211,0.0001615195,0.000283308,0.0006281218,0.0007991967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003830797,"about_ca_system_score_gemma":0.0002131063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007060472,"about_ca_topic_score_gemma":0.0006881203,"domain_scores_codex":[0.9996566,0.00004111229,0.00004362813,0.00009752541,0.0001205501,0.00004054661],"domain_scores_gemma":[0.9998329,0.00003729744,0.00004044164,0.00003916984,0.00002251726,0.00002765421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001747952,0.00001150068,0.00003777854,0.00001189473,0.000002346341,0.00002570792,0.000005550949,0.00004984756,0.9994298,0.00006926835,0.00004027734,0.0002984172],"study_design_scores_gemma":[0.000001605811,0.00003127829,0.000250208,7.195525e-7,0.000001289194,0.00004210905,0.000002358433,0.0002512796,0.9989296,0.00001051505,0.000477982,0.000001134506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725831,0.0008473515,0.01872479,0.0002342628,0.00008506918,0.0001266372,0.00110319,0.0005045937,0.005790986],"genre_scores_gemma":[0.9873033,0.0002641969,0.005514881,0.00009129598,0.000005634877,0.00004941892,0.0007305176,0.00009595021,0.005944676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001947651,"threshold_uncertainty_score":0.006515503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009429592107996423,"score_gpt":0.2405605991644288,"score_spread":0.2311310070564323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}