{"id":"W2885654872","doi":"10.1158/1538-7445.am2018-1763","title":"Abstract 1763: BiTEs vs CAR-Ts: Preclinical targeting of CD133+ brain tumor initiating cells using immunotherapy-based treatment strategies","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University","funders":"","keywords":"Chimeric antigen receptor; Antigen; Immunotherapy; Cytotoxic T cell; Cancer research; Brain tumor; Antibody; Monoclonal antibody; Glioma; T cell; Tumor antigen; Immunology; Biology; Medicine; Immune system; Pathology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002901512,0.0006657198,0.000517957,0.0004031953,0.0002028069,0.0003549605,0.0003837585,0.0007363994,0.00346494],"category_scores_gemma":[0.0001004498,0.0001921253,0.0003686065,0.0002514345,0.0003680036,0.0002902201,0.0001915989,0.001800297,0.0006654457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000326603,"about_ca_system_score_gemma":0.0005816915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008730486,"about_ca_topic_score_gemma":0.0007798203,"domain_scores_codex":[0.9998233,0.00002674475,0.00001311769,0.00002841791,0.00004785789,0.0000605605],"domain_scores_gemma":[0.9999347,0.000008735805,0.00001305967,0.000006585026,0.00000803829,0.0000288809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002809191,0.002802223,0.0001595217,0.0001710568,0.00003380296,0.00009058771,0.00005778734,0.001029855,0.9820179,0.0008152475,0.001097922,0.008914799],"study_design_scores_gemma":[0.0005163217,0.017897,0.0007999755,0.00001277905,0.00005822941,0.0001496546,0.00002897202,0.00178554,0.9734115,0.0001478697,0.00518017,0.00001193456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873253,0.001530592,0.003895783,0.0003683458,0.0001957846,0.0007415228,0.001259753,0.0002671046,0.004415812],"genre_scores_gemma":[0.9864276,0.001242236,0.0040327,0.0002036162,0.00003861373,0.0005360262,0.001192611,0.0000501206,0.006276531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00346494,"threshold_uncertainty_score":0.01159137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1844756257654731,"score_gpt":0.4928505953804103,"score_spread":0.3083749696149372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}