{"id":"W2885675181","doi":"10.1101/gad.312173.118","title":"Distinct patterns of histone acetyltransferase and Mediator deployment at yeast protein-coding genes","year":2018,"lang":"en","type":"article","venue":"Genes & Development","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics and Genomics of Geneva; National Institutes of Health; Institute of Genetics; National Institute of General Medical Sciences; Canton de Genève","keywords":"Biology; RNA polymerase II; Mediator; Histone acetyltransferase; Coactivator; Acetyltransferase; Genetics; Gene; Histone Acetyltransferases; Histone; Cell biology; Transcription factor II D; Transcription (linguistics); Transcription factor; Gene expression; RNA polymerase; RNA; Promoter; Acetylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000163526,0.000172883,0.0002101486,0.0005188081,0.0001421637,0.0003527095,0.0002438205,0.0002298514,0.0009371369],"category_scores_gemma":[0.0003664566,0.00026642,0.0002155939,0.0002669526,0.0003606085,0.0002578121,0.0004865995,0.0003805264,0.0003080886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002388749,"about_ca_system_score_gemma":0.0001312476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000526892,"about_ca_topic_score_gemma":0.001051292,"domain_scores_codex":[0.9996643,0.00002538412,0.00002343178,0.000133691,0.00008191681,0.00007126135],"domain_scores_gemma":[0.9996459,0.00006654823,0.00009212577,0.00005995864,0.00005521337,0.00008025939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001126311,0.000005222447,0.00223082,0.0000135301,0.000007671407,0.00002585448,0.00002471582,0.00004111708,0.9959018,0.0001215695,0.00001178604,0.001503263],"study_design_scores_gemma":[0.00002434744,0.0001960029,0.2338041,0.000008753156,0.0000468732,0.0006688181,0.0001616439,0.001092136,0.7620736,0.0003115468,0.001593767,0.00001845647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949044,0.0009997601,0.002495895,0.00004608547,0.000007207502,0.000007949035,0.0003012093,0.00005511859,0.001182322],"genre_scores_gemma":[0.9968171,0.0002367922,0.0009826021,0.00003309764,0.0000040583,0.00001579514,0.0005098866,0.0000237087,0.001377022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009371369,"threshold_uncertainty_score":0.003135026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007831100863978433,"score_gpt":0.233667786737816,"score_spread":0.2258366858738376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}