{"id":"W2885744227","doi":"10.1016/j.chom.2018.07.009","title":"A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus","year":2018,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":242,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Ragon Institute of MGH, MIT and Harvard; Public Health Agency of Canada; Massachusetts General Hospital","keywords":"Ebola virus; Virology; Monoclonal antibody; Antibody; Biology; Neutralization; Ebolavirus; Neutralizing antibody; Antibody-dependent enhancement; Immune system; Virus; Immunology; Viral replication","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001274628,0.0008941648,0.0004411524,0.0006352103,0.0004417514,0.001012698,0.0008725742,0.00136837,0.003924965],"category_scores_gemma":[0.000994783,0.0002116455,0.0004210756,0.0001574185,0.000610291,0.001109131,0.0004197533,0.001369178,0.0005753497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001315429,"about_ca_system_score_gemma":0.0004819717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001642219,"about_ca_topic_score_gemma":0.0005496408,"domain_scores_codex":[0.9995911,0.0001536689,0.00002378347,0.00004257943,0.00005226268,0.0001365203],"domain_scores_gemma":[0.9996713,0.0001427292,0.00003900868,0.00005749438,0.00005473928,0.00003480602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003287714,0.0003178076,0.001561408,0.0003619292,0.00008346891,0.000550668,0.0001572551,0.001053291,0.9257506,0.01217721,0.001140202,0.05355863],"study_design_scores_gemma":[0.0006738422,0.003701955,0.009278568,0.0001655621,0.0003889015,0.002716212,0.0001925762,0.01177891,0.9395555,0.003729044,0.02779544,0.00002352491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9152247,0.03577014,0.02440642,0.002463883,0.0004107318,0.0003500178,0.0003967549,0.0004823536,0.02049491],"genre_scores_gemma":[0.9930041,0.001589328,0.002838117,0.000220474,0.00006352782,0.00004853079,0.0001191825,0.00001836114,0.002098275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003924965,"threshold_uncertainty_score":0.01313031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02188984474126734,"score_gpt":0.3054251211416381,"score_spread":0.2835352764003708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}