{"id":"W2885835268","doi":"10.1101/386680","title":"Genome Wide Meta-Analysis identifies new loci associated with cardiac phenotypes and uncovers a common genetic signature shared by heart function and Alzheimer’s disease","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; CurePSP; Servier; Eisai; European Federation of Pharmaceutical Industries and Associations; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Mayo Foundation for Medical Education and Research; F. Hoffmann-La Roche; University of Southern California; Mayo Clinic; GlaxoSmithKline; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Foundation for the National Institutes of Health; European Commission; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Genome-wide association study; Disease; Phenotype; Genetic association; Biology; Gene; Heart disease; Genetics; Genetic architecture; Bioinformatics; Single-nucleotide polymorphism; Medicine; Genotype; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004325121,0.001255791,0.002923447,0.003965465,0.0006720783,0.002630716,0.001078691,0.001042874,0.003915043],"category_scores_gemma":[0.006491651,0.0006218682,0.01010501,0.005639208,0.000477885,0.0006997118,0.001473086,0.001615039,0.0003178304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003718997,"about_ca_system_score_gemma":0.0006522611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003557485,"about_ca_topic_score_gemma":0.004378373,"domain_scores_codex":[0.9961033,0.001462437,0.0003559046,0.00142382,0.0003560667,0.0002985243],"domain_scores_gemma":[0.9921578,0.004604687,0.0009809415,0.001593848,0.0002516989,0.0004110191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003540878,0.00007803684,0.725369,0.001683772,0.2368688,0.001169709,0.0001594431,0.002810653,0.008421551,0.0005862355,0.002416988,0.01689475],"study_design_scores_gemma":[0.0002752965,0.0003118032,0.8640295,0.00030398,0.1194613,0.00133707,0.0002372896,0.00677674,0.00177403,0.002366526,0.003064254,0.00006211867],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9037952,0.06258056,0.01609492,0.002089874,0.0003347163,0.00005554208,0.01242845,0.0006050196,0.002015569],"genre_scores_gemma":[0.9900852,0.004239059,0.001977847,0.0001924594,0.0001242786,0.00003412014,0.002915092,0.0000966768,0.0003351555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004325121,"threshold_uncertainty_score":0.0228737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01275274117743534,"score_gpt":0.2168529978962969,"score_spread":0.2041002567188616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}