{"id":"W2885846020","doi":"10.1158/0008-5472.can-18-0618","title":"Replication Protein A Availability during DNA Replication Stress Is a Major Determinant of Cisplatin Resistance in Ovarian Cancer Cells","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôtel-Dieu de Montréal; Université Laval; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Cisplatin; DNA damage; DNA replication; DNA repair; Replication protein A; Nucleotide excision repair; Biology; Cell biology; Eukaryotic DNA replication; Replication factor C; Cancer research; Cell culture; DNA; Molecular biology; Genetics; DNA-binding protein; Transcription factor; Gene; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009868345,0.0001494765,0.0002292753,0.0002319461,0.0001335905,0.0002849718,0.00008853513,0.0001465325,0.001104993],"category_scores_gemma":[0.0001617016,0.0001133426,0.0001227981,0.000239782,0.0001152275,0.0001151991,0.0001829452,0.0002301426,0.0002492606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001687834,"about_ca_system_score_gemma":0.0001375733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009687486,"about_ca_topic_score_gemma":0.001010674,"domain_scores_codex":[0.9998946,0.000016092,0.00001696393,0.00002451567,0.00002784275,0.00001997056],"domain_scores_gemma":[0.9998561,0.00003406292,0.00002913273,0.00002408706,0.00002666566,0.00002989016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001103477,0.00001723007,0.004256524,0.00002442522,0.000007466645,0.00007061801,0.00002218893,0.00006464385,0.9942379,0.00002908477,0.0000450769,0.001114469],"study_design_scores_gemma":[0.00001444876,0.000723986,0.1256634,0.000007740475,0.00003395606,0.001142945,0.0001363859,0.001823822,0.8675485,0.00004634475,0.002850641,0.000007858988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975759,0.001002899,0.0005546468,0.0000291071,0.00000541476,0.00001550155,0.000352425,0.00002613589,0.0004378814],"genre_scores_gemma":[0.9986395,0.0002608459,0.0002484773,0.00001668367,0.000002535876,0.00001492666,0.0004457534,0.000004073614,0.0003671558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001104993,"threshold_uncertainty_score":0.003696501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.032526580124558,"score_gpt":0.3621449714801736,"score_spread":0.3296183913556156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}