{"id":"W2885849072","doi":"10.1007/s10549-018-4910-z","title":"Letrozole concentration is associated with CYP2A6 variation but not with arthralgia in patients with breast cancer","year":2018,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre; University of Toronto; Centre for Addiction and Mental Health; Western University","funders":"Canadian Institutes of Health Research; Cancer Care Ontario; AstraZeneca; Canada Research Chairs; Amgen","keywords":"Letrozole; Breast cancer; Medicine; Oncology; Internal medicine; Cancer; Gynecology; Tamoxifen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002587112,0.0002599581,0.0005247892,0.0007929282,0.0003027311,0.0005025283,0.0003040507,0.0005693731,0.001781465],"category_scores_gemma":[0.002426571,0.0002323408,0.0004744163,0.001222842,0.0002449905,0.0002742873,0.0001787922,0.00056171,0.000232294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002156256,"about_ca_system_score_gemma":0.0001397011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001613431,"about_ca_topic_score_gemma":0.001675557,"domain_scores_codex":[0.999508,0.0001506543,0.00006354191,0.0001279104,0.00008907458,0.00006073362],"domain_scores_gemma":[0.998087,0.0006260156,0.0008856329,0.0001298695,0.0001209852,0.0001505008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008223866,0.00003440289,0.9934883,0.00001991316,0.0002220382,0.0002780668,0.00006634475,0.00004173495,0.002334253,0.00002597627,0.0001150518,0.002551654],"study_design_scores_gemma":[0.00001508621,0.000133219,0.998342,0.000003655134,0.00009586394,0.0007756109,0.00004964257,0.0001114959,0.0002296789,0.00003206027,0.0002068973,0.000004813848],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980162,0.0009798554,0.0001079321,0.00009143473,0.00001591966,0.000003805921,0.000248006,0.000009198227,0.00052749],"genre_scores_gemma":[0.9995247,0.0001003233,0.00004614692,0.00003171026,0.00001792568,0.000002298784,0.000115323,0.000003221606,0.0001585004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001781465,"threshold_uncertainty_score":0.00595957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007562068540441,"score_gpt":0.274370671019837,"score_spread":0.2642950503344326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}