{"id":"W2885851270","doi":"10.1097/shk.0000000000001243","title":"Part I: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Study Design and Humane Modeling Endpoints","year":2018,"lang":"en","type":"review","venue":"Shock","topic":"Animal testing and alternatives","field":"Veterinary","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Sepsis; Medicine; Blinding; Septic shock; Intensive care medicine; Clinical trial; Clinical study design; Endpoint Determination; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003034536,0.0005579986,0.002300568,0.0001360818,0.0001786257,0.00005719001,0.0003687603,0.0002177451,0.00001613359],"category_scores_gemma":[0.001570543,0.0004374984,0.000309931,0.0001289498,0.0001386966,0.00009379286,0.000395739,0.0004209783,0.00002979032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008995883,"about_ca_system_score_gemma":0.00008797484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002136685,"about_ca_topic_score_gemma":0.00003374984,"domain_scores_codex":[0.995907,0.0008776002,0.001458129,0.001077515,0.0002465944,0.0004331602],"domain_scores_gemma":[0.9957424,0.003110323,0.0004426577,0.0004930457,0.0001234323,0.00008807667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003444637,0.004584321,0.001926261,0.08443429,0.00712365,0.0005281685,0.01555565,0.0001100526,0.00000403886,0.0003444489,0.007770286,0.8741742],"study_design_scores_gemma":[0.01443397,0.07064834,0.0003573355,0.2078093,0.01171364,0.0003709691,0.02418453,0.05966652,0.000004511821,0.02825696,0.5701617,0.01239218],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01606451,0.979844,0.0006538552,0.000009706739,0.0003255059,0.002775184,0.00005809338,0.0001106937,0.0001584223],"genre_scores_gemma":[0.01046409,0.9831116,0.004367821,0.0000256331,0.0008135973,0.0005651069,0.00002019427,0.0001039001,0.0005280917],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.861782,"threshold_uncertainty_score":0.9998077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8395421268594873,"score_gpt":0.610081113564286,"score_spread":0.2294610132952013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}