{"id":"W2885867927","doi":"10.1016/j.bbagen.2018.08.008","title":"“Pinching” the ammonia tunnel of CTP synthase unveils coordinated catalytic and allosteric-dependent control of ammonia passage","year":2018,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - General Subjects","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University","keywords":"Glutaminase; Glutamine amidotransferase; Allosteric regulation; Chemistry; ATP synthase; GTP'; Active site; Glutamine; Biochemistry; Stereochemistry; Enzyme; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003625046,0.0004076989,0.0004834549,0.00008423883,0.0001526906,0.00005357322,0.00065585,0.000289032,0.000008625863],"category_scores_gemma":[0.0001575763,0.0003021905,0.0002318403,0.0002828013,0.0009940923,0.00001322047,0.0005174134,0.0002518769,0.000007555775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000243808,"about_ca_system_score_gemma":0.0001706038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004383382,"about_ca_topic_score_gemma":0.00009856532,"domain_scores_codex":[0.9975423,0.000277602,0.0004952566,0.0007160027,0.0004000651,0.0005687387],"domain_scores_gemma":[0.99829,0.00005686086,0.0003168929,0.0008392399,0.0002706595,0.0002263193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007009921,0.0002958817,0.00004243119,0.00008683621,0.0002786985,0.000006198117,0.0001046862,0.000001485529,0.9973487,0.00007497322,0.0004724312,0.0005866395],"study_design_scores_gemma":[0.001616697,0.0009934171,0.002703279,0.00004372205,0.0001150995,0.00002073999,0.0000359406,0.0001821018,0.9935864,0.00009203731,0.0002573133,0.0003532628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971488,0.0004948796,0.0001814693,0.001003709,0.0001108204,0.0005491535,0.0002327199,0.00002031418,0.0002582108],"genre_scores_gemma":[0.9983218,0.0001668213,0.0002413953,0.0004675348,0.0002774465,0.00003825257,0.0001734035,0.00005596835,0.0002574176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003762358,"threshold_uncertainty_score":0.999943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009394971841765517,"score_gpt":0.2542663535782128,"score_spread":0.2448713817364473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}