{"id":"W2885935805","doi":"10.1161/circgen.118.002165","title":"Genetic Regulation of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Plasma Levels","year":2018,"lang":"en","type":"letter","venue":"Circulation Genomic and Precision Medicine","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Clinical Research Institute","funders":"","keywords":"Kexin; PCSK9; Subtilisin; Proprotein convertase; Proprotein Convertases; LDL receptor; Chemistry; Endocrinology; Cholesterol; Biology; Biochemistry; Lipoprotein; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00115197,0.000440483,0.001268908,0.0004535539,0.0001315189,0.00001589709,0.0001526965,0.0009922266,0.001690261],"category_scores_gemma":[0.0003820809,0.0003512372,0.0002103724,0.0002919632,0.0003895141,0.00006494729,0.00006872699,0.0007462467,0.00008310497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001724212,"about_ca_system_score_gemma":0.0003661504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002306053,"about_ca_topic_score_gemma":0.000004893331,"domain_scores_codex":[0.9962968,0.0002751081,0.001151737,0.0007855512,0.001128512,0.0003622417],"domain_scores_gemma":[0.9971855,0.0001677682,0.000600183,0.001148809,0.0006867676,0.0002109421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001333853,0.00009800922,0.008073955,0.005170764,0.001116122,0.0002661408,0.001826003,0.00009314768,0.0604894,0.00005657163,0.5515988,0.3698772],"study_design_scores_gemma":[0.005611994,0.001250527,0.4608332,0.00213101,0.001162006,0.0006518467,0.00006405261,0.003113453,0.001260055,0.001232271,0.5221109,0.0005787177],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8986701,0.01146415,0.005896122,0.07602827,0.001960435,0.004364179,0.00009237378,0.000112394,0.001412004],"genre_scores_gemma":[0.9199374,0.0008329922,0.002671549,0.05876515,0.01349259,0.00005140369,0.001259973,0.000183735,0.002805167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4527592,"threshold_uncertainty_score":0.999894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03828867792389773,"score_gpt":0.2730591423783572,"score_spread":0.2347704644544594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}