{"id":"W2885953918","doi":"10.1158/1557-3265.sarcomas17-b06","title":"Abstract B06: Targeting PI3K/mTOR in mouse rhabdomyosarcoma models driven by FGFR4 activation","year":2018,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"PI3K/AKT/mTOR pathway; Cancer research; Protein kinase B; Rhabdomyosarcoma; Biology; Oncogene; Cell culture; Cell; Cell cycle; Sarcoma; Signal transduction; Medicine; Cell biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002759045,0.0006875474,0.0004048929,0.000762218,0.0001956079,0.0003238466,0.0003582836,0.0005240391,0.001840175],"category_scores_gemma":[0.00009262591,0.0002505463,0.0005198068,0.0003354723,0.0002384332,0.0002042627,0.0001470237,0.00103199,0.0006380195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005093584,"about_ca_system_score_gemma":0.0004082283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001652765,"about_ca_topic_score_gemma":0.003432716,"domain_scores_codex":[0.9997335,0.00003630088,0.00003139279,0.00004997878,0.00008325218,0.00006556205],"domain_scores_gemma":[0.9998931,0.00001110762,0.00002824066,0.00001367005,0.00001599668,0.00003790911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004508967,0.0002795818,0.0001501347,0.00006091734,0.000013453,0.00004726049,0.00001254801,0.0002985878,0.9962848,0.0001290277,0.0002487409,0.002023968],"study_design_scores_gemma":[0.00007663479,0.002852598,0.001752468,0.000009333393,0.00002428061,0.0001469382,0.00002029921,0.0008785649,0.9917877,0.00003009829,0.002414111,0.000006983406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863602,0.001487764,0.003069398,0.0002586553,0.00009524692,0.0002850613,0.003981948,0.0003476487,0.004113961],"genre_scores_gemma":[0.9756883,0.001790118,0.00734461,0.0001354239,0.00001753328,0.0003228477,0.0047686,0.00006202182,0.009870466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001840175,"threshold_uncertainty_score":0.006155968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1384394694771033,"score_gpt":0.4746343058332434,"score_spread":0.3361948363561401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}