{"id":"W2886012932","doi":"10.1002/anie.201808560","title":"Nickel‐Catalyzed Amide Bond Formation from Methyl Esters","year":2018,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Catalysis; Amide; Stoichiometry; Nickel; Chemistry; Alcohol; Coupling reaction; Peptide bond; Combinatorial chemistry; Organic chemistry; Polymer chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009531843,0.0001259219,0.0001097541,0.00004345437,0.00006166822,0.00004907596,0.00020174,0.0001208964,0.0003683802],"category_scores_gemma":[0.0001517459,0.0001204211,0.000134247,0.00006789093,0.0000830936,0.00002893582,0.00007707712,0.00005674488,0.00008776598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004823738,"about_ca_system_score_gemma":0.00001518305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000827191,"about_ca_topic_score_gemma":0.00006083261,"domain_scores_codex":[0.9991266,0.00001131381,0.0002228363,0.0002807243,0.0002232515,0.0001353228],"domain_scores_gemma":[0.9994147,0.00002305649,0.0001238351,0.0001909776,0.0001833006,0.00006411975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005595308,0.0000363472,0.0001863825,0.000002706536,0.00009608422,7.327189e-7,0.00003287838,8.493048e-7,0.9753442,0.00001950343,0.02266088,0.001563417],"study_design_scores_gemma":[0.0003273033,0.00002276399,0.0003823521,0.00001955535,0.00003675986,0.000003228047,0.00005497746,0.00008512144,0.951172,0.000454074,0.0472998,0.0001420494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722497,0.0001361418,0.01731312,0.001173734,0.0006412676,0.00007282625,0.0002185928,0.00002929704,0.008165275],"genre_scores_gemma":[0.9899743,0.0001025432,0.000777613,0.0004843523,0.003346027,0.00002104355,0.004881517,0.00001420363,0.0003984654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02463892,"threshold_uncertainty_score":0.4910631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076590943260494,"score_gpt":0.2544118890296778,"score_spread":0.2436459795970729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}