{"id":"W2886013928","doi":"10.1007/s13402-018-0397-1","title":"Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones","year":2018,"lang":"en","type":"article","venue":"Cellular Oncology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of General Medical Sciences; Lung Cancer Research Foundation","keywords":"Apoptosis; Leukemia; Cancer research; Lymphoma; Proteasome; Chemistry; Pharmacology; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003499923,0.0001930967,0.0002707372,0.0001039024,0.00006720386,0.000008273573,0.0001237665,0.0003800353,0.0000695378],"category_scores_gemma":[0.00003094091,0.0001995969,0.00008952774,0.0001747833,0.0002855331,0.000008388231,0.0001186288,0.000109754,0.00004815682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000161943,"about_ca_system_score_gemma":0.0002058479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001653774,"about_ca_topic_score_gemma":0.00003950852,"domain_scores_codex":[0.9985096,0.0002186678,0.0003854073,0.0004283386,0.0001308891,0.0003270619],"domain_scores_gemma":[0.9992608,0.00001063823,0.0002065469,0.000307572,0.0001280302,0.0000863506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001884487,0.0002194436,0.000169542,0.00003245814,0.00001882893,0.000004789345,0.0001255304,0.000009736692,0.9811049,0.00003071827,0.0009664695,0.01712915],"study_design_scores_gemma":[0.001586037,0.00143119,0.00009418269,0.00002117241,0.00001413864,0.00002388198,0.00007853237,0.00008487088,0.9698444,0.0001894252,0.02642546,0.0002067143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933923,0.0003968139,0.003251069,0.0001196699,0.0004256136,0.0005166842,0.0000225146,0.00001604733,0.001859226],"genre_scores_gemma":[0.9979635,0.00008516003,0.0006986807,0.0001843165,0.00046814,0.0001170348,0.0001953155,0.00002891918,0.0002588754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02545899,"threshold_uncertainty_score":0.8139325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102602729391856,"score_gpt":0.2458202244408511,"score_spread":0.2347941971469326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}