{"id":"W2886023030","doi":"10.1242/jcs.211672","title":"Sorting nexin-21 is a scaffold for the endosomal recruitment of huntingtin","year":2018,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Medical Research Council Canada; Wellcome Trust","keywords":"Sorting nexin; Biology; Retromer; Endosome; Huntingtin; Septin; Cell biology; Interactome; Function (biology); Scaffold protein; Population; Computational biology; Genetics; Signal transduction; Gene; Cytokinesis; Cell division","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009763536,0.0000569403,0.00008529467,0.00003741718,0.0001447591,0.00002056907,0.0003089087,0.00003329602,0.00001788793],"category_scores_gemma":[0.00005516351,0.00003733717,0.0001141127,0.0001200708,0.0002788109,0.00000848423,0.0000296998,0.00004096419,8.297076e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008086288,"about_ca_system_score_gemma":0.0001544337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003697182,"about_ca_topic_score_gemma":0.000005447828,"domain_scores_codex":[0.9992044,0.000009434358,0.0002824262,0.0001123416,0.0002312966,0.0001600967],"domain_scores_gemma":[0.9991366,0.00001674519,0.0003559334,0.0001339449,0.0003086792,0.00004813564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006015419,0.00002420174,0.001342559,0.000007921476,0.000006313048,4.24467e-7,0.0002058957,0.000006253537,0.9965648,0.00004185893,0.0000566112,0.001682978],"study_design_scores_gemma":[0.0002849619,0.0004882243,0.001588295,0.00001594431,0.00002062607,0.00001059007,0.0001511153,0.000261644,0.9726489,0.00005899246,0.02442506,0.00004565007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772104,0.0003706035,0.02093988,0.0002203885,0.0002540065,0.000138741,0.000001641678,8.902158e-7,0.0008634216],"genre_scores_gemma":[0.9969762,0.00006085041,0.002247393,0.000115392,0.0003423817,0.000002008191,0.00000214087,0.00000434103,0.0002492978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02436845,"threshold_uncertainty_score":0.1522566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03223364524635968,"score_gpt":0.2885325983303815,"score_spread":0.2562989530840218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}