{"id":"W2886122726","doi":"10.1002/bit.26810","title":"Glycan‐masking hemagglutinin antigens from stable CHO cell clones for H5N1 avian influenza vaccine development","year":2018,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Ministry of Science and Technology, Taiwan","keywords":"Biology; Virology; Heterologous; Glycan; Chinese hamster ovary cell; Antigen; Hemagglutinin (influenza); Influenza A virus subtype H5N1; Glycosylation; Antibody; Influenza vaccine; Molecular biology; Vaccination; Glycoprotein; Cell culture; Immunology; Genetics; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002857922,0.000404634,0.0002995012,0.000227211,0.0002065692,0.0003774394,0.0004159991,0.0003348594,0.0008583492],"category_scores_gemma":[0.0001932882,0.0002046489,0.0003206848,0.000338546,0.0001400484,0.0002071394,0.0002971262,0.0008542353,0.0008563947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004095909,"about_ca_system_score_gemma":0.000242092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009395355,"about_ca_topic_score_gemma":0.001510769,"domain_scores_codex":[0.9998124,0.00003488255,0.00002178722,0.0000253601,0.00007271666,0.00003286768],"domain_scores_gemma":[0.9998956,0.00001608278,0.00002275254,0.00002761156,0.00002363996,0.00001434477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002366562,0.00001325568,0.00009617272,0.00001560821,0.000002638025,0.00001896419,0.00001322108,0.0000324171,0.9990221,0.00006583325,0.00002425369,0.0006718813],"study_design_scores_gemma":[0.00001804791,0.0002335273,0.001942753,0.000004806634,0.00002395864,0.0002419746,0.00002793821,0.0009481629,0.9917871,0.00003534221,0.004730502,0.000005823587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750387,0.0008013426,0.01994692,0.0001211621,0.00006954404,0.0003105624,0.001137098,0.0001095466,0.002465192],"genre_scores_gemma":[0.9511158,0.001225174,0.03642789,0.0001034005,0.00002176431,0.0003545949,0.004944691,0.00009619912,0.005710516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009395355,"threshold_uncertainty_score":0.002971768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04410554217873144,"score_gpt":0.312502623702023,"score_spread":0.2683970815232916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}