{"id":"W2886122726","doi":"10.1002/bit.26810","title":"Glycan‐masking hemagglutinin antigens from stable CHO cell clones for H5N1 avian influenza vaccine development","year":2018,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Ministry of Science and Technology, Taiwan","keywords":"Biology; Virology; Heterologous; Glycan; Chinese hamster ovary cell; Antigen; Hemagglutinin (influenza); Influenza A virus subtype H5N1; Glycosylation; Antibody; Influenza vaccine; Molecular biology; Vaccination; Glycoprotein; Cell culture; Immunology; Genetics; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002039951,0.0002540257,0.0003935372,0.0003188572,0.0002910947,0.00002076621,0.0001368796,0.0003750251,0.00003056879],"category_scores_gemma":[0.0001495041,0.0002203114,0.00004476875,0.0002798701,0.0001595722,0.00006722024,0.0002218039,0.0002870538,0.0000303658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008410659,"about_ca_system_score_gemma":0.00007830859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005329481,"about_ca_topic_score_gemma":0.00004666742,"domain_scores_codex":[0.9984824,0.000007216884,0.000320658,0.0004133874,0.0001382757,0.0006380631],"domain_scores_gemma":[0.9993505,0.00006700576,0.00006219855,0.0002874729,0.0001230262,0.0001097423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007411038,0.0001471284,0.04327141,0.0005545174,0.0006062836,0.00004906079,0.001136001,0.00002104354,0.9152219,0.000489915,0.0007530488,0.03700856],"study_design_scores_gemma":[0.001827511,0.000301269,0.01871274,0.0001508626,0.00004775315,0.0000129255,0.000208599,0.001054825,0.7875831,0.00002885397,0.1898143,0.0002572057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807441,0.004471468,0.01236443,0.0009394559,0.0001967874,0.0007135466,0.00003291101,0.0004077894,0.0001294601],"genre_scores_gemma":[0.9587209,0.0003697522,0.03997794,0.0003282877,0.0002897257,0.00008845121,0.00001794103,0.00004127214,0.0001657157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1890613,"threshold_uncertainty_score":0.8984037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04410554217873144,"score_gpt":0.312502623702023,"score_spread":0.2683970815232916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}