{"id":"W2886127471","doi":"10.1016/j.cell.2018.07.020","title":"Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Compass; Methyltransferase; EZH2; Methylation; Histone; Enhancer; Cell biology; Histone methyltransferase; Chromatin; Computational biology; Genetics; DNA; Physics; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001305062,0.000221507,0.0002137958,0.000187609,0.0007320069,0.000628713,0.0007465801,0.0002930782,0.004110625],"category_scores_gemma":[0.0003329431,0.0002976127,0.0001501697,0.0002592208,0.0004876683,0.0005929942,0.0003024283,0.0008987581,0.0003460521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001329335,"about_ca_system_score_gemma":0.0004043695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00516973,"about_ca_topic_score_gemma":0.005135704,"domain_scores_codex":[0.9999199,0.000005850828,0.000002945204,0.00002999367,0.00001795546,0.00002331552],"domain_scores_gemma":[0.9998649,0.0000289708,0.00002623588,0.00001462626,0.00001374728,0.00005151463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002525887,0.0006662844,0.01438037,0.0002306213,0.0003248995,0.001191451,0.0008974375,0.03517276,0.9019951,0.01962784,0.004959199,0.01802815],"study_design_scores_gemma":[0.0003078272,0.0009423972,0.05420252,0.00004952241,0.0001501661,0.0007377893,0.001273542,0.3208555,0.5953877,0.007515262,0.01824666,0.0003310405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995748,0.0004500005,0.001262305,0.0003567563,0.00003228056,0.000005058044,0.0001498688,0.00003995773,0.001955692],"genre_scores_gemma":[0.9971649,0.0002829084,0.0005124138,0.0000706332,0.000008049554,0.000005339115,0.0003843569,0.00001543961,0.001555849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00516973,"threshold_uncertainty_score":0.01375145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01074265514730436,"score_gpt":0.262380672094729,"score_spread":0.2516380169474247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}