{"id":"W2886127471","doi":"10.1016/j.cell.2018.07.020","title":"Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Compass; Methyltransferase; EZH2; Methylation; Histone; Enhancer; Cell biology; Histone methyltransferase; Chromatin; Computational biology; Genetics; DNA; Physics; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006097581,0.00007000646,0.00008688767,0.00002332432,0.00004200599,0.000006424026,0.0000581623,0.00007226926,0.00007104164],"category_scores_gemma":[0.00000853559,0.00006767381,0.00002398313,0.00003216806,0.0001464186,0.000001897823,0.00002444315,0.00003233359,0.000001558463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006775619,"about_ca_system_score_gemma":0.00002423648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001373075,"about_ca_topic_score_gemma":0.00005508324,"domain_scores_codex":[0.999579,0.00002089175,0.0001398789,0.0001111012,0.00006945213,0.00007967082],"domain_scores_gemma":[0.9996663,0.000007983276,0.00004930006,0.0001270492,0.0001087971,0.0000405794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002548927,0.00001606217,0.0007932192,0.00002630617,0.000009460673,1.115878e-7,0.00007405592,0.00002131538,0.9976162,0.0003506137,0.0001483135,0.0009188459],"study_design_scores_gemma":[0.0004267131,0.000198999,0.007428579,0.000002520303,0.0000118771,0.000001277853,0.00003042821,0.002746958,0.981347,0.0005518965,0.007161831,0.00009190528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837065,0.0004063837,0.01294481,0.00005678762,0.00006242523,0.00007269742,0.0001227433,0.000002956976,0.002624743],"genre_scores_gemma":[0.9965923,0.00005331665,0.002612659,0.00005685256,0.00006879903,9.888705e-7,0.0004911041,0.000006666626,0.0001173555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01626919,"threshold_uncertainty_score":0.2759658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01074265514730436,"score_gpt":0.262380672094729,"score_spread":0.2516380169474247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}