{"id":"W2886135244","doi":"10.1126/sciadv.aar6637","title":"A mouse model of 22q11.2 deletions: Molecular and behavioral signatures of Parkinson’s disease and schizophrenia","year":2018,"lang":"en","type":"article","venue":"Science Advances","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Rehabilitation Institute; University Health Network; Centre for Addiction and Mental Health","funders":"National Center for Research Resources; National Institute of Mental Health; National Institutes of Health; Canadian Institutes of Health Research; Maryland Stem Cell Research Fund; McLaughlin Centre, University of Toronto; National Alliance for Research on Schizophrenia and Depression; NIH Office of the Director; U.S. Department of Defense; Stanley Foundation","keywords":"Schizophrenia (object-oriented programming); Disease; Parkinson's disease; Genetics; Biology; Deletion syndrome; Neuroscience; Medicine; Psychiatry; Gene; Pathology; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001467007,0.00007024177,0.00008171568,0.00007492212,0.00008600422,0.00001486067,0.0001513,0.00002857892,0.000002355832],"category_scores_gemma":[0.0001052682,0.00006205881,0.00002159327,0.000150642,0.001755574,0.00002155294,0.0001747351,0.00003896146,3.40677e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003832419,"about_ca_system_score_gemma":0.000142452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008290749,"about_ca_topic_score_gemma":0.00003358312,"domain_scores_codex":[0.9992198,0.00001691133,0.0000996763,0.0002803068,0.0002179647,0.0001653371],"domain_scores_gemma":[0.999451,0.000006659811,0.00003650327,0.0002019068,0.0001808926,0.000123001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001056843,0.00002917913,0.001568059,0.00002098161,0.000002441087,5.82202e-7,0.00002332059,0.00006552208,0.989031,0.000092004,0.000003838709,0.009057458],"study_design_scores_gemma":[0.0002032439,0.0003505129,0.001785769,0.0000133729,0.000009571093,0.000001389554,0.00003764706,0.001527279,0.9951298,0.0005909167,0.0002626882,0.00008780378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941321,0.005170809,0.0004518176,0.00002479089,0.0000151448,0.0001169539,0.00003852068,0.000003415892,0.00004644245],"genre_scores_gemma":[0.9965329,0.0001915029,0.003167619,0.00001980695,0.00001446578,0.000008596019,0.000002510287,0.000005099491,0.00005752665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008969653,"threshold_uncertainty_score":0.6468484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01452439536836195,"score_gpt":0.3209041118556542,"score_spread":0.3063797164872922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}