{"id":"W2886228434","doi":"10.1158/1078-0432.ccr-18-0717","title":"Targeting the CDK4/6-Rb Pathway Enhances Response to PI3K Inhibition in <i>PIK3CA</i> -Mutant Lung Squamous Cell Carcinoma","year":2018,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"PI3K/AKT/mTOR pathway; In vivo; Cancer research; Medicine; Mutant; Lung cancer; Biology; Oncology; Signal transduction; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009045387,0.0002667983,0.0005510381,0.0002918951,0.0003973782,0.0000633388,0.0003606925,0.0002197828,0.0005974892],"category_scores_gemma":[0.003153547,0.0001898326,0.0001533455,0.001433085,0.001146995,0.0001603728,0.000366996,0.001611852,0.0002623024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000779803,"about_ca_system_score_gemma":0.001306756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008138866,"about_ca_topic_score_gemma":0.000713124,"domain_scores_codex":[0.9939786,0.001697358,0.001005083,0.0009262534,0.001229853,0.001162919],"domain_scores_gemma":[0.9945619,0.003127092,0.0001491976,0.0008242658,0.000885395,0.0004521242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.05244188,0.0007824435,0.0457499,0.0002852688,0.00003406922,0.0005214685,0.005023455,0.00007348585,0.8445837,0.00007107117,0.006939474,0.04349373],"study_design_scores_gemma":[0.01068798,0.007134661,0.1044336,0.0008564898,0.00004795302,0.00005186102,0.004855852,0.0008342374,0.7343206,0.000901828,0.1350944,0.0007804747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980966,0.002988029,0.0002824809,0.01268777,0.0005556707,0.001495607,0.00003734817,0.00006608151,0.0009210225],"genre_scores_gemma":[0.9928765,0.0001456139,0.0003371655,0.002634074,0.002384964,0.000551278,0.000007486654,0.0000751474,0.000987733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.128155,"threshold_uncertainty_score":0.7741149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09080625717076041,"score_gpt":0.4630727496974689,"score_spread":0.3722664925267085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}