{"id":"W2886245611","doi":"10.1002/jcph.1280","title":"Abuse Potential of Buprenorphine/Samidorphan Combination Compared to Buprenorphine and Placebo: A Phase 1 Randomized Controlled Trial","year":2018,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Buprenorphine; Placebo; Medicine; Opioid; Crossover study; Anesthesia; Pharmacology; Adverse effect; Partial agonist; Opioid use disorder; Antagonist; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002529781,0.002414472,0.00459382,0.0006387862,0.000647451,0.001531164,0.001481807,0.002786364,0.01478979],"category_scores_gemma":[0.002845391,0.001205986,0.002999716,0.0007622812,0.001241784,0.001608598,0.0004928403,0.003325823,0.001681331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009548336,"about_ca_system_score_gemma":0.001351426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009433276,"about_ca_topic_score_gemma":0.002220836,"domain_scores_codex":[0.9985698,0.0007364139,0.0001157888,0.0003039096,0.0001362856,0.0001376803],"domain_scores_gemma":[0.9985722,0.0004897999,0.0003908335,0.0001055574,0.0001608046,0.0002807225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9764949,0.008004217,0.0001681075,0.001971888,0.001505987,0.00003036442,0.00004130758,0.0001396999,0.001398242,0.00009634473,0.0006395766,0.00950935],"study_design_scores_gemma":[0.9582346,0.03994815,0.000406926,0.00007432267,0.0005265931,0.00001504707,0.00001528569,0.0001863916,0.0001214412,0.00008685912,0.0003729179,0.00001140387],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9108199,0.03244678,0.003107313,0.00206107,0.002787594,0.03847111,0.003609024,0.000546873,0.006150307],"genre_scores_gemma":[0.9326221,0.01526256,0.005093286,0.002533769,0.001622494,0.03529896,0.00154572,0.00006761011,0.005953456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01478979,"threshold_uncertainty_score":0.0494768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03413364598482498,"score_gpt":0.4165368754345509,"score_spread":0.3824032294497259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}