{"id":"W2886291380","doi":"10.1158/1557-3265.hemmal17-39","title":"Abstract 39: XPO1 inhibitor, KPT-8602, is well tolerated and highly active against AML blasts and LICs","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Tolerability; Medicine; Internal medicine; Oncology; Pharmacology; Chemotherapy; Leukemia; Cancer research; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001885823,0.0004134497,0.0004885976,0.0001839887,0.0001675642,0.0003044156,0.0002980463,0.0003322731,0.003733687],"category_scores_gemma":[0.00013262,0.0001398434,0.000178289,0.0002249335,0.0001503221,0.0001934121,0.0001612425,0.000938154,0.00120398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000225945,"about_ca_system_score_gemma":0.0003320682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006004002,"about_ca_topic_score_gemma":0.0007458218,"domain_scores_codex":[0.9998324,0.00002465345,0.00002056966,0.00002338364,0.00006157485,0.00003727758],"domain_scores_gemma":[0.9999104,0.000009505874,0.00001694591,0.00001106037,0.00001302619,0.00003913703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002097777,0.001259194,0.001140885,0.0001575619,0.00003954096,0.0003048795,0.00004250083,0.0006311386,0.9671841,0.000241249,0.002465518,0.02443573],"study_design_scores_gemma":[0.001806343,0.02126724,0.02811439,0.00001887591,0.0001258274,0.004118741,0.00003478573,0.003128412,0.9113677,0.000114604,0.02988007,0.00002312324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817544,0.004072253,0.002799267,0.0003073038,0.00008009421,0.0002713048,0.002853046,0.0004678125,0.007394577],"genre_scores_gemma":[0.9831802,0.001441359,0.0015427,0.0001567962,0.00003220139,0.000117581,0.007320668,0.00003169438,0.006176882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003733687,"threshold_uncertainty_score":0.01249045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08652697351121018,"score_gpt":0.4459001832331325,"score_spread":0.3593732097219223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}