{"id":"W2886321703","doi":"10.1038/s41467-018-05395-y","title":"The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; McMaster University","funders":"Terry Fox Foundation","keywords":"Chimeric antigen receptor; Cytotoxic T cell; CD28; Cancer research; Cytokine release syndrome; Cytokine; Antigen; CD8; Cytotoxicity; T-cell receptor; Immunotherapy; T cell; In vitro; Chemistry; Biology; Immunology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001963524,0.0003502314,0.0002232716,0.0002059756,0.0001337457,0.0006030018,0.0002352596,0.0006611868,0.001118418],"category_scores_gemma":[0.00015917,0.0001516747,0.0002537046,0.0001683228,0.0001995312,0.0003309257,0.0001877398,0.0006903368,0.0005364507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003389181,"about_ca_system_score_gemma":0.0002428095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000498348,"about_ca_topic_score_gemma":0.0005460862,"domain_scores_codex":[0.999787,0.00003216037,0.00001880092,0.00004595676,0.00006446127,0.0000515089],"domain_scores_gemma":[0.9998622,0.00002279183,0.00003793521,0.00002265776,0.00002938888,0.0000250303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000435933,0.00002073927,0.00005181865,0.00001602799,0.000003395893,0.00003095948,0.000003765272,0.00009402342,0.9982147,0.0001838147,0.00008655674,0.0012507],"study_design_scores_gemma":[0.00001301762,0.0001491388,0.0002518945,0.000001588591,0.00001105088,0.0002511885,0.000005170008,0.001059916,0.9960784,0.0000251336,0.002150598,0.00000289074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96351,0.001998638,0.02603455,0.0004070684,0.0001223147,0.00008513711,0.0002742382,0.0004640376,0.00710406],"genre_scores_gemma":[0.9860547,0.0005515744,0.009524095,0.0001111704,0.00001919109,0.00002714685,0.0002451895,0.00003740443,0.003429582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001118418,"threshold_uncertainty_score":0.003741503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04732461507935709,"score_gpt":0.3628452382667252,"score_spread":0.3155206231873681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}